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Mechanisms of Epidermal Growth Factor Receptor Regulation of Epidermal Proliferation and Skin Tumorigenesis in Response to Ultraviolet Irradiation.
(Creighton University, 2004-08)
The epidermal growth factor receptor (EGFR), a receptor tyrosine kinase, regulates both skin biology and carcinogenesis. We hypothesized that EGFR-dependent signal transduction increases normal keratinocyte proliferation ...