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dc.contributor.advisorTownley, Robert G.en_US
dc.contributor.authorAdolphson, Richard Louisen_US
dc.date.accessioned2018-06-01T16:50:03Z
dc.date.available2018-06-01T16:50:03Z
dc.date.issued1970en_US
dc.identifier.urihttp://hdl.handle.net/10504/118281
dc.description.abstractThe action of prostaglandin F2a (PGF2a)1 on guinea-pig isolated trachea has been studied. Special emphasis was placed on considerations of the possible beta-adrenergic blocking activities of this essential fatty-acid derivative. | Experiments were performed using a 20 ml tissue bath and a modified phosphate-Tyrode solution. Measurements were made by an isotonic myograph and displayed on a Physiograph recorder. | Cumulative log dose-response curves to isoproterenol before and after either PGF2a or a beta blocker (MJ 1999) provided data for calculating and plotting both isoboles and Lineweaver-Burk curves. These, calculations indicated that PGF2a is not inhibitory to the action of isoproterenol on guinea-pig trachea in vitro. | Further experiments demonstrated that PGF2a possesses a weak inhibitory activity on methacholine-induced tracheal tone. That this inhibitory activity is not mediated through the beta- adrenergic receptor was shown in experiments where beta blocker (MJ 1999) failed to inhibit the activity of PGF2a. Inhibition of methacholine-induced tone by PGF2a was further differentiated from that produced by isoproterenol on the basis of observations that PGF2a-induced inhibition was incomplete, even at the highest concentrations.en_US
dc.language.isoen_USen_US
dc.publisherCreighton Universityen_US
dc.rightsA non-exclusive distribution right is granted to Creighton University and to ProQuest following the publishing model selected above.en_US
dc.titleA Study of the Action of Prostaglandin F2a on the Guinea-Pig Isolated Tracheaen_US
dc.typeThesis
dc.publisher.locationOmaha, Nebraskaen_US
dc.description.noteProQuest Traditional Publishing Optionen_US
dc.contributor.cuauthorAdolphson, Richard Louisen_US
dc.degree.levelMS (Master of Science)en_US
dc.degree.disciplinePhysiology and Pharmacology (graduate program)en_US
dc.degree.nameM.S. in Physiology and Pharmacologyen_US
dc.degree.grantorGraduate Schoolen_US


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