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dc.contributor.advisorFerraro, Frank M.en_US
dc.contributor.authorOrtez, Richard A.en_US
dc.date.accessioned2018-06-15T16:21:21Z
dc.date.available2018-06-15T16:21:21Z
dc.date.issued1972en_US
dc.identifier.urihttp://hdl.handle.net/10504/118379
dc.description.abstractThe basal and epinephrine-aminophyllin altered in vivo levels of cyclic AMP content of liver, diaphragm and spleen of normal CFW female mice were determined. Epinephrine-aminophyllin administration was shown to increase the cyclic AMP content by varying amounts; liver 12%, diaphragm 104% and spleen 58%. Bordete11a pertussis vaccination was observed to inhibit these epinephrine-aminophyllin mediated increases in cyclic AMP content. The time at which this inhibition was evident after vaccination differed with the tissue examined. The pertussis induced inhibition of the epinephrine, as well as NaF, mediated increases in adenyl cyclase activity were also shown to exist under in vitro conditions for these three tissues. In vivo administration of beta-adrenergic blocking agents profoundly inhibited the functioning of the adenyl cyclase systems of diaphragm and spleen but not that of liver. Spleen capsule and lymphoid elements of normal mice were shown to contain adenyl cyclase activities which differed from one another in epinephrine sensitivity and susceptibility to pertussis induced alteration. Adenyl cyclase derived from platelets was shown to possess an unusually high rate of activity under resting conditions. This rate of activity was subject to an epinephrine mediated inhibition. Epinephrine mediated diminution in cyclic AMP production by platelet adenyl cyclase was reversed by prior pertussis vaccination.en_US
dc.language.isoen_USen_US
dc.publisherCreighton Universityen_US
dc.rightsA non-exclusive distribution right is granted to Creighton University and to ProQuest following the publishing model selected above.en_US
dc.subjectMicrobiologyen_US
dc.titleThe Effect of Bordetella Pertussis Vaccination on the Adrenergically Induced Synthesis of Cyclic 3',5'-Adenosine Monophosphate (Cyclic Amp) in Murine Tissuesen_US
dc.typeDissertation
dc.publisher.locationOmaha, Nebraskaen_US
dc.description.noteProQuest Traditional Publishing Optionen_US
dc.contributor.cuauthorOrtez, Richard A.en_US
dc.degree.levelPhD (Doctor of Philosophy)en_US
dc.degree.disciplineMedical Microbiology (graduate program)en_US
dc.degree.namePh.D. in Medical Microbiologyen_US
dc.degree.grantorGraduate Schoolen_US


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