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dc.contributor.advisorMcKercher, Theodore C.en_US
dc.contributor.authorBoudro, Martin Anthonyen_US
dc.date.accessioned2019-01-03T16:51:59Z
dc.date.available2019-01-03T16:51:59Z
dc.date.issued1975en_US
dc.identifier.urihttp://hdl.handle.net/10504/120892
dc.description.abstractDuring one episode in the British quest for antimalarial agents a class of compounds was discovered to have antibacterial activity. Investigators at Imperial Chemical Industries Ltd., Manchester, England found that certain bisbiguanides, especially chlorhexidine, were effective in this latter respect. | Bisbiguanide compounds were examined extensively at ICI from the late nineteen forties but the results of these investigations were not published until 1954 when G.E. Davies et.al. reported the bacteriostatic, bactericidal and toxic effects of chlorhexidine. Both gram positive and gram negative bacteria were susceptible but only a very weak action against bacterial spores was observed. Action against hemolytic streptococci in infected artificial wounds was good. Attempts to establish resistant bacterial strains were unsuccessful with their experimental methods. In mice extremely low oral toxicity (LD50 2,000 mg/kg) was found although intravenous toxicity (LD50 25 mg/kg) was comparatively high. There was no interference with phagocytosis of staphylococci by human leucocytes in vitro.en_US
dc.language.isoen_USen_US
dc.publisherCreighton Universityen_US
dc.rightsA non-exclusive distribution right is granted to Creighton University and to ProQuest following the publishing model selected above.en_US
dc.titleThe Toxicity of Chlorhexidins on Mammalian Connective Tissue and Vasculatureen_US
dc.typeThesis
dc.publisher.locationOmaha, Nebraskaen_US
dc.description.noteProQuest Traditional Publishing Optionen_US
dc.contributor.cuauthorBoudro, Martin Anthonyen_US
dc.degree.levelMS (Master of Science)en_US
dc.degree.disciplineDentistry (graduate program)en_US
dc.degree.nameM.S. in Dentistryen_US
dc.degree.grantorGraduate Schoolen_US


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