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Regulation of Retinal Glutamate Release by Peroxides
(Creighton University, 2002)
Hydrogen peroxide (H2O2), a reactive oxygen metabolite, has been localized in the neural retina and pigment epithelium of some vertebrate species. Although oxidative stress has been implicated in some retinal disorders ...
Study of Receptor Binding and Growth Effect of Gastrin Gene Products
(Creighton University, 2002)
Colorectal cancer is the third leading cancer in US, accounted for 160,000 cases and 57,000 deaths per year. Gastrin (G17) has been postulated as a growth factor for colorectal cancer development. Gastrin, a heptadecapeptide, ...
Expression of Suppressors of Cytokine Signaling Proteins in Airway Epithelial Cells
(Creighton University, 2007-07)
Since their discovery, Suppressors of Cytokine Signaling, or SOCS proteins, have been found in numerous cell types, but their role in asthma is not completely clear. Although the exact mechanisms are unclear and interpretations ...
Neurally Released Nitric Oxide does not Oppose Reflex Cholinergic Contraction of Airway Smooth Muscle in Dogs
(Creighton University, 2001)
When afferent nerve endings in the airway detect a foreign substance, centrally mediated reflexes, acting through cholinergic parasympathetic efferents, contract airway smooth muscle. It has been proposed that these efferents ...
Pharmacological Studies of the Signal Transduction Pathways of the a 1a-Adrenbrgic Receptor Subtype
(Creighton University, 2003-05)
Alpha 1-adrenergic receptors (a1-ARs) are a heterogeneous group of G protein- coupled seven transmembrane receptors that mediate the actions of the endogenous catecholamines, norepinephrine and epinephrine. Three 1a-AR ...
Sequence-Based Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus
(Creighton University, 2003-12-12)
Methicillin-resistant S. aureus (MRSA) are a major cause of nosocomial infections requiring accurate and rapid molecular techniques for epidemiological analysis. Increased genomic sequence information has resulted in the ...
Carotid Atherosclerosis: Why Some Patients are Symptomatic and Others Not?
(Creighton University, 2002-12)
Occlusive vascular disease (OVD) is the leading cause of morbidity and mortality in the United States. OVD of the carotid arteries results in stroke or transient ischemic attacks. A significant number of strokes are caused ...
Expression of Usherin in Human Tissues: Implications for Diagnostics and Pathology
(Creighton University, 2002-05-18)
Usher Syndrome is an autosomal recessive disease that results in varying degrees of hearing loss and retinitis pigmentosa. Three types of Usher Syndrome (1,11, and III) have been identified clinically with Usher type II ...
Biochemical Studies on Uncoupling Proteins and Glucose Metabolism in Skeletal Muscle
(Creighton University, 2002)
Uncoupling protein (UCP) is an inner-mitochondrial membrane protein that uncouples the production of ATP from the electron transport chain, thereby inducing thermogenesis. Recently, a family of UCP homologues was identified, ...
Prion Strain Diversity and Molecular Properties of PrPsc
(Creighton University, 2003-09-11)
The transmissible spongiform encephalopathies or prion diseases are a group of uniformly fatal neurodegenerative diseases that affect both humans and animals. The agent of these diseases is proposed to consist solely of ...