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The V(D)J Recombinase: Toward A Mechanistic Understanding Of Its Cleavage Activity
(Creighton University, 2008-06-10)
Introduction. V(D)J recombination is a form of site-specific DNA rearrangement that is responsible for assembling antigen receptor genes during lymphocyte development. This process is initiated when two lymphoid cell ...
Role of Membrane-Type Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinase-2 in Neural Crest Cell Migration
(Creighton University, 2005)
During embryonic development, cardiac neural crest {NC) cells arise from the dorsal portion of the neural tube through an epithelial-to-mesenchymal transition and then migrate into the pharyngeal arches and subsequently ...
Chloride Channels in Normal Human Blood Monocytes and a Macrophage-like Cell Line
(Creighton University, 2004-11)
Phagocytic cells serve critical roles in the body’s immune response by recognizing, phagocytosing and destroying foreign particles. A major class of phagocytic cells is composed of monocytes and macrophages. During ...
The Influence of ampC Expression and Penicillin Binding Protein Binding on the Variation of ß-lactam Induction Potential in Three Genera of Enterobacteriaceae
(Creighton University, 2006-04-08)
Citrobacter freundii, Enterobacter cloacae, and Serratia marcescens are members of the Enterobacteriaceae family and are significant nosocomial pathogens. These organisms encode inducible, chromosomal AmpC ß-lactamases ...
Generation and analysis of transgenetic mice expressing catalytically inactive recombination activating gene-1
(Creighton University, 2006-05)
The proteins encoded by the recombination activating genes (RAG1 and RAG2) are lymphoid cell-specific endonucleases that initiate V(D)J recombination; the mechanism by which the exons that encode the variable portion of ...
Genome-Wide Linkage Scan and Association Analyses for Obesity Genes
(Creighton University, 2005-08)
Obesity is a condition of excess body fat that causes or exacerbates several major public health problems. Common obesity is a polygenic disorder arising from the interaction of multiple genetic and environmental factors. ...
A Mucoadhesives in Situ Gel Delivery System for Paclitaxel.
(Creighton University, 2006-08)
MUC1 gene encodes a transmembrane mucin glycoprotein that is over expressed in human breast cancer and colon cancer. The underlying hypothesis of this investigation was that a mucoadhesive in situ gel delivery system ...
TRAIL and TGF-ßl-Induced Apoptosis of Human Airway Epithelial Cells
(Creighton University, 2006-07)
Asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness (AHR), airway obstruction, wheezing, and leads to airway remodeling if these symptoms persist. Airway remodeling is characterized by ...
Regulation of STAT6 and STAT4 Phosphorlation by Histamine
(Creighton University, 2006-11)
Signal transducer and activators of transcription (STAT) - 6 and STAT4 are the transcriptional factors crucial for the T helper cell differentiation into Thl and Th2 respectively. STAT6 is activated in response to IL-4 and ...
Multiplex PCR Assay for Detection of USA300 Community-Associated Methicillin-Resistant Staphylococcus aureus
(Creighton University, 2006-12-12)
Recent reports have noted a discernible increase in the number of community- associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections in patients without traditional risk factors. In the United States, ...