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The Missing Founding Fathers: The Need to Teach the Role of the Antifederalists in the Adoption of the Bill of Rights
(Creighton University, 2009-12-01)
This thesis examines the need to place more emphasis on teaching the role of the Antifederalists in the 1787-88 debate over the adoption of the U.S. Constitution to high school history and government students. The cited ...
Sequence and Structure Specific Cleavage of Cryptic Recombination Signal Sequences by the V(D)J Recombinase
(Creighton University, 2009-12)
Introduction Immune repertoire diversity is largely achieved by a process termed V(D)J recombination, during which functional antigen receptor genes are assembled from discrete gene segments through site-specific DNA ...
Development and Characterization of Polymeric Nanoparticulate Delivery System for Hydrophillic Drug: Gemcitabine.
(Creighton University, 2009-12)
Gemcitabine is a nucleoside analogue, used in various carcinomas such as non small cell lung cancer, pancreatic cancer, ovarian cancer and breast cancer. The major setbacks to the conventional therapy with gemcitabine ...
Purification of Human Immunodeficiency Virus Type 1 Preintegration Complexes by Velocity Gradient Centrifugation.
(Creighton University, 2009-12-11)
The early events of human immunodeficiency virus type 1 (HIV-1) infection are mediated by two large nucleoprotein complexes (NPCs), the reverse transcription complex (RTC) and the preintegration complex (PIC). These ...
Mycobacterial Antigens and Immunomodulation in Allergic Asthma
(Creighton University, 2003-02)
The disease asthma is characterized by the hallmark features of airway hyperresponsiveness (AHR), increased serum concentrations of IgE and type 2 cytokines, and tissue and bronchoalveolar lavage (BAL) eosinophilia. It has ...
The Na/K-ATPase in the gills of Antarctic and New Zealand nototheniids: The Physiologic and Molecular Effects of Warm-acclimation.
(Creighton University, 2002)
Antarctic fish, living in -2°C waters, have a serum osmolality of « 600mOsm/kg nearly double that of temperate teleosts. The increase in serum osmolality is due to proportional increases in the Na" and CT concentrations ...
Functional Roles of A1-adrenergic Receptors in the Bovine Inferior Alveolar Artery: Regulation of Contraction and Activation of Extracellular Signal Regulated Kinase
(Creighton University, 2002-06)
The bovine inferior alveoiar artery (BIAA) runs inside the length of the mandibie and branches to form dental arteries that supply blood to the teeth. I investigated the effects of 5-hydroxytryptamine (5-HT), acetylcholine ...
STARlight: A C++ Object-Oriented Monte Carlo Event Generator for Ultra-Peripheral Collisions
(Creighton University, 2009-12-25)
Ultra-peripheral collisions occur when nuclei pass one another without overlapping. The intense electric fields present can be treated as a flux of virtual photons; these photons can interact with the other nucleus or each ...
In vivo Genome-wide Expression Study on Human Blood B cells Suggests a Novel ESRI and MAPK3 Network for Postmenopausal Osteoporosis
(Creighton University, 2007-05)
Osteoporosis is characterized by low BMD resulting from bone resorption (by osteoclasts) exceeding bone formation (by osteoblasts). In postmenopausal women, estrogen deficiency evokes increased osteoclastic activity and ...
Hope from within: Reform in the Islamic Republic and Ayatollah Montazeri's Mission to Fulfill the Promises of the Iranian Revolution
(Creighton University, 2009-05-15)
The primary purpose of this project was to demonstrate the strong degree of support for reform in Iran from within the clergy. Additionally, this study sought an understanding of why the reform movement had failed and ...