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A Molecular and Pharmacological Study of the α1- Adregenergic Receptors: From the Novel Alternatively Spliced α1A-AR Isoforms to the Acute Effects of the Triiodothyronine
(Creighton University, 2002-12-06)
Numerous literary works dating as far back as the turn of the 19th century contain precise physiological descriptions of adrenergic stimulatory effects on the human body, which offer testimony to our interest in adrenergic ...
Effects of Gentamicin on Cochlear Hair Cell Metabolism
(Creighton University, 2009-08-01)
In the mammalian cochlea, hair cells convert the mechanical energy of sound to electrical signals in the auditory nerve, and are therefore an essential component of hearing. One cause of sensorineural hearing loss is through ...
Dynamic Light Scattering in Glassforming Aqueous Maltose
(Creighton University, 2008-08)
We report results of a photon correlation spectroscopy study of the glassforming dynamics in aqueous maltose solutions of varying concentration. These measurements represent a companion study to earlier measurements conducted ...
Mycobacterial Antigens and Immunomodulation in Allergic Asthma
(Creighton University, 2003-02)
The disease asthma is characterized by the hallmark features of airway hyperresponsiveness (AHR), increased serum concentrations of IgE and type 2 cytokines, and tissue and bronchoalveolar lavage (BAL) eosinophilia. It has ...
The Na/K-ATPase in the gills of Antarctic and New Zealand nototheniids: The Physiologic and Molecular Effects of Warm-acclimation.
(Creighton University, 2002)
Antarctic fish, living in -2°C waters, have a serum osmolality of « 600mOsm/kg nearly double that of temperate teleosts. The increase in serum osmolality is due to proportional increases in the Na" and CT concentrations ...
Functional Roles of A1-adrenergic Receptors in the Bovine Inferior Alveolar Artery: Regulation of Contraction and Activation of Extracellular Signal Regulated Kinase
(Creighton University, 2002-06)
The bovine inferior alveoiar artery (BIAA) runs inside the length of the mandibie and branches to form dental arteries that supply blood to the teeth. I investigated the effects of 5-hydroxytryptamine (5-HT), acetylcholine ...
Design, Synthesis and Pharmacological Characterization of Novel Calcitonin Gene-Related Peptide Receptor Antagonists
(Creighton University, 2006-06)
ABSTRACT|Human-a-calcitonin gene-related peptide (CGRP) is a 37 amino acid residue neuropeptide produced from tissue-specific alternative splicing of the primary RNA transcript of the calcitonin gene. CGRP is widely ...
The Influence of ampC Expression and Penicillin Binding Protein Binding on the Variation of ß-lactam Induction Potential in Three Genera of Enterobacteriaceae
(Creighton University, 2006-04-08)
Citrobacter freundii, Enterobacter cloacae, and Serratia marcescens are members of the Enterobacteriaceae family and are significant nosocomial pathogens. These organisms encode inducible, chromosomal AmpC ß-lactamases ...
Genome-Wide Linkage Scan and Association Analyses for Obesity Genes
(Creighton University, 2005-08)
Obesity is a condition of excess body fat that causes or exacerbates several major public health problems. Common obesity is a polygenic disorder arising from the interaction of multiple genetic and environmental factors. ...
Regulation of STAT-1 Phosphorylation by Histamine Through H1 and H2 Receptors: Inverse Agonism and PKA-PKC Interaction in STAT-1 Phosphorylation
(Creighton University, 2005-05-05)
Signal transducer and activator of transcription-1 (STAT1) is a latent signal transducer protein which, on phosphorylation, is translocated from the cytoplasm to the nucleus and is subsequently activated. This work was ...