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Now showing items 1-10 of 162
Molecular Characterization of Fluoroquinolone Resistance in Streptococcus pneumoniae
(Creighton University, 2006-05-05)
Streptococcus pneumoniae is a leading cause of respiratory tract infections, meningitis, and acute otitis media. The emergence of S. pneumoniae strains with resistance to the ß-lactam and macrolide antibiotics has complicated ...
Genetic Linkage and Association Studies for Bone Geometry and Bone Mineral Density
(Creighton University, 2007-04)
Osteoporosis is a common skeletal disease becoming one of the biggest public health menaces with the consequence of millions of fractures annually around the world. Osteoporosis is mainly characterized by compromised bone ...
Regulation of IL-13 by Histamine
(Creighton University, 2001)
According to the 1997 National Health Interview Study by the National Center for Health Statistics and the Center for Disease Control and Prevention, it was estimated that 25.7 million people had been diagnosed with asthma. ...
Upregulation of PIP3-dependent RAC Exchanger 1 (P-Rex1) Promotes Prostate Cancer Metastasis
(Creighton University, 2008-08-18)
Activation of Rac by guanine-nucleotide exchange factors (GEFs) at the leading edge of the cell plays an important role in directional cell migration, a critical step of tumor metastasis cascades. We investigated the role ...
TGF-β1-induced Chloride Channel Activity and Migration of Human Eosinophils
(Creighton University, 2009-05)
Asthma is a chronic disease of the airways characterized by airway hyperresponsiveness, airway inflammation, and airway remodeling. Eosinophils migrate to the airways and play a significant role in the pathogenesis of ...
A Study of the Causal Factors of Civil War in the 1990s
(Creighton University, 2009-07-14)
In recent decades there has been a rise in intrastate conflicts. This thesis explores the causes of civil war, focusing on ethnic, religious, institutional and economic factors contributing to or alleviating internal ...
Development and Characterization of Nanoparticulate Delivery System for the Radioprotectant Drug Amifostine
(Creighton University, 2008-05)
Amifostine is a cytoprotectant drug used as an adjunct in cancer chemotherapy and radiation therapy. A simple and sensitive HPLC method was developed and validated for the assay of Amifostine. The method consisted of 95:5 ...
TH17 Cells and Suppressor of Cytokine Signaling in House Dust Mite Model of Asthma: Effect of by FLT-3 Ligand
(Creighton University, 2009-04-06)
Asthma is a chronic inflammatory disorder of the airways. In this disease an allergic reaction occurs that shifts T-helper (Th) cells towards a Th2 subtype response to innocuous antigen characterized by a predominant ...
Successful Women Leaders in the Workplace: Advice to Fill a Briefcase for Success
(Creighton University, 2009-01-13)
This thesis addresses the following research question: what are the steps a young professional woman can take right now-this minute-in order to achieve organizational leadership and success in Omaha, Nebraska in the near ...
In Vitro Characterization of Proglucagon Cleavage by PCI
(Creighton University, 2002)
The activation of many biologically active peptides occurs through the sequential action of propeptide converting enzymes on less active precursors called propeptides. Propeptide converting enzymes recognize and cleave ...