BETA-lactam antibiotics are the largest class of antimicrobial drugs and the most frequently prescribed world wide. As the use of these agents increased so did the evolution of bacterial BETA-lactam resistance. BETA-lactamases ...

The relationship between mechanical loading and adaptive changes in bony architecture was noted more than one hundred years ago, however, the mechanism of this process is still not understood. Effects of mechanical loading ...

Occlusive vascular disease is one of the major causes of morbidity and mortality in the United States. Treatment often involves angioplasty and stenting. In 30-50% of angioplasty cases, success is limited by re-narrowing ...

(First paragraph of Introduction)|The development of neural projections and the establishment of functioning neural circuits are crucial developmental events in an animal's life since they underlie both perceptive and ...

Bone is an organ that is highly sensitive to changes in its mechanical loading environment. Although it is known that increased mechanical loading results in new bone formation, the cellular mechanisms underlying this ...

Estrogen receptor-alpha (ERa) mediates diverse estrogen functions through transactivation of target gene expression and the membrane-associated signaling pathways. Recently, we identified and cloned a novel variant of ERa, ...

Eosinophils are one of the major effector cells in asthma, and controlling the number and survival of eosinophils might attenuate the severity of asthma. This could be achieved by inducing eosinophil apoptosis. Apoptosis ...

Osteoporosis and obesity are two complex diseases that are prevalent in the United States. Obesity is a condition of excess body fat that exacerbates several major public health problems. Osteoporosis is a skeletal disease ...

Asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness (AHR), airway obstruction, wheezing, and leads to airway remodeling if these symptoms persist. Airway remodeling is characterized by ...

Gene-encoded antimicrobial peptides are an important component of host defense in both invertebrates and vertebrates, ranging from insects to mammals. Although these peptides are usually isolated in high concentrations, ...