Now showing items 1-6 of 6
Structure-Function and Behavioral Studies on the Glutamate Delta-1 Receptor
(Creighton University, 2012-01-18)
The delta family of ionotropic glutamate receptors (iGluRs) consists of glutamate delta-1 (GluD1) and glutamate delta-2 (GluD2) receptors. The function of GluD1 in the central nervous system (CNS) remains elusive. As a ...
Inner Ear Hair Cell Loss and Stereocilia Defects in miR-183 Family Knockout Models
(Creighton University, 2015-05-26)
Hearing loss is the most prevalent sensory defect, and although hearing aids and cochlear implants can provide sensory input, no current therapeutic options exist for restoration of normal hearing. The microRNA-183 family ...
MicroRNAs are essential for hair cell development.
(Creighton University, 2008-10-10)
MicroRNAs are small non-coding RNAs that are processed through an endogenous biological pathway and function to post-transcriptionally regulate target gene expression. MicroRNAs affect cellular proliferation, differentiation, ...
The Role of CDC25A in Ultraviolet-induced Nonmelanoma Skin Tumorigenesis
(Creighton University, 2010-11-28)
Cell division cycle 25A (CDC25A) is a dual-specificity phosphatase that removes inhibitory phosphate groups from cyclin-dependent kinases, allowing cell cycle progression. Activation of cell cycle checkpoints following ...
Regulation of ERK1/2 and SAPK/JNK Phosphorylation by Histamine
(Creighton University, 2009-12)
Mitogen activated protein kinases (MAPKs) are specific serine/threonine kinases which respond to various stimuli and control various cellular activities including gene expression, mitosis, cell differentiation, and cell ...
Studies of GluN2C-containing NMDA Receptors in Schizophrenia-like Behaviors and Fear Learning: Relevance to the Glutamate Hypofunction Hypothesis of Schizophrenia
(Creighton University, 2012-12-11)
N-methyl-D-aspartate (NMDA) receptors play an important role in excitatory neurotransmission and mediate synaptic plasticity associated with learning and memory and are postulated to play an important role in numerous ...