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The Role of Bradykinin Antagonists in Experimental Acute Spinal Cord Injury
(Creighton University, 2003)
Bradykinin, following activation of the Kinin-Kallikrein cascade in acute spinal cord injury (ASCI), acts on the B2 receptors of blood vessels and neurons causing vasogenic edema, inflammation and neuronal death. This study ...
Cholecystokinin Action at CCK1 Receptors in the Brain to Produce Satiety in Rats
(Creighton University, 2001)
Cholecystokinin (CCK) is a peptide that is found throughout the brain and in neurons and endocrine cells of the gastrointestinal tract. Studies demonstrating that systemic administration of the CCK1 receptor antagonist ...
Cellular Responses to Short-Term Mechanical Loading: Relative Involvement of Osteoblasts, Pre-Osteoblasts, and Osteoprogenitor Cells
(Creighton University, 2002)
Bone is an organ that is highly sensitive to changes in its mechanical loading environment. Although it is known that increased mechanical loading results in new bone formation, the cellular mechanisms underlying this ...
Modulation of Osteoblast Differentiation in Rat Calvarial Cells: Investigations into Effects of Mechanical Load and Interleukin-1β
(Creighton University, 2000-07)
The relationship between mechanical loading and adaptive changes in bony architecture was noted more than one hundred years ago, however, the mechanism of this process is still not understood. Effects of mechanical loading ...
Comparison of Ecto-Nucleotidase Activity in PAR-C5 Cells and Native Rat Parotid Gland
(Creighton University, 2002-12)
Cells from a parotid gland acinar cell line (PAR-C5) cells were investigated to compare the activity of the ecto-nucleotidase enzyme in those cells to those of native parotid gland acinar cells. The object of this study ...