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Small RNA Sequencing Analysis of Inner Ear from Conditional Knockout Mice with Hair Cell-Specific Dgcr8 or Dicer1 Deletion
(Creighton University, 2016-01-08)
Damage to mechanosensory hair cells (HCs) of the inner ear leads to permanent hearing loss. Small RNAs, namely endogenous small interfering RNAs (endo-siRNAs) and canonical microRNAs, are known to affect HC development and ...
Identifying microRNAs Involved in the Onset and Progression of Age-Related Hearing Loss
(Creighton University, 2013-07-24)
Age-related hearing loss (ARHL) is a progressive sensorineural hearing loss that occurs as people get older. It is generally accepted that degeneration of the organ of Corti and atrophy of the stria vascularis in the inner ...
Inner Ear Hair Cell Loss and Stereocilia Defects in miR-183 Family Knockout Models
(Creighton University, 2015-05-26)
Hearing loss is the most prevalent sensory defect, and although hearing aids and cochlear implants can provide sensory input, no current therapeutic options exist for restoration of normal hearing. The microRNA-183 family ...