Search
Now showing items 1-10 of 14
Characterizing Deleterious Genomic Mutations in The Presence of Overdominance (a Computer Simulation Approach)
(Creighton University, 2000)
Most mutations with observable phenotypic effects are harmful. Characterizing Deleterious Genomic Mutations (DGMs) is essential in testing the numerous theories that have been developed to explain some fundamental biological ...
Modulation of Osteoblast Differentiation in Rat Calvarial Cells: Investigations into Effects of Mechanical Load and Interleukin-1β
(Creighton University, 2000-07)
The relationship between mechanical loading and adaptive changes in bony architecture was noted more than one hundred years ago, however, the mechanism of this process is still not understood. Effects of mechanical loading ...
Isolation, Structures, Synthesis and Biological Activities of Non-Mammalian Vertebrate Endothelins
(Creighton University, 2000)
The endothelins (ETs) are a family of peptides that have the most potent and long-lasting vasoconstrictivity yet described. They have been shown to exhibit a wide variety of pharmacological activities and may play diverse ...
Characterizing Deleterious Genomic Mutations in Simulated Populations Under Some Biologically Realistic Situations
(Creighton University, 2000)
The DENG-LYNCH method was developed to estimate the rate and effects of deleterious genomic mutations (DGM) in natural populations under the assumptions that populations are infinite with unlinked loci, completely outcrossing ...
Development of an Implantable Doxorubicin Delivery System for the Treatment of Bone Cancer
(Creighton University, 2000)
Doxorubicin, an anthracycline cytostatic antibiotic, is widely used in cancer chemotherapy. It has one of the widest anticancer spectrums, especially effective in the treatments of soft tissue and bone sarcomas. However, ...
Power Analysis and Extension of a Robust Test of Linkage and Association of Human Complex Disease Genes
(Creighton University, 2000-08)
The main focus of this work is a modern approach for gene mapping of complex human diseases, the Transmission/Disequilibrium Test (TDT). My studies demonstrate that the TDT is a robust, nuclear family based analysis that ...
Parathyroid Hormone-Related Peptide Immunolocalization During Early Chick Cardiac Development
(Creighton University, 2000)
Parathyroid hormone-related peptide (PTHrP) has been implicated in mediating proliferation and differentiation in various tissues in the developing embryo but its role in early heart development has not been investigated. ...
Regulation of Vascular Smooth Muscle Cell Apoptosis by Insulin-like Growth Factor-1: Control of Apoptosis Induced by C-MYC and Protein Kinase Inhibition
(Creighton University, 2000-06-15)
The biological actions of insulin-like growth factor-1 (IGF-1) are critical from embryonic development through adulthood. IGF-1 exerts its actions almost exclusively through the IGF-1 receptor (IGF-1 R), perpetuating a ...
Robustness And Power of a TDT Statistic for Mapping Quantitative Trait Loci
(Creighton University, 2000-08)
The transmission disequilibrium test (TDT), originally developed for mapping disease genes, has recently been extended to the identification of quantitative trait loci (QTLs). A general TDT (TDTG) has been developed to ...
Molecular and Pharmacological Studies of Alpha1-AR Subtypes and their Signaling Pathways
(Creighton University, 2000-12)
Studies in part 1 of this dissertation were intended to develop selective inhibitors of (aiBAR and ajo-AR, respectively) subtype expression using antisense oligomer approaches. Using the nucleotide sequence of the (Xib-AR ...