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Local Control of Blood Flow in the Bronchial Circulation of Dogs
(Creighton University, 2000)
The bronchial circulation supplies nutritive flow to the conducting airways.I studied the local control of blood flow in the bronchial circulation of dogs. The three aims of my study of the bronchial circulation were to ...
Robustness And Power of a TDT Statistic for Mapping Quantitative Trait Loci
(Creighton University, 2000-08)
The transmission disequilibrium test (TDT), originally developed for mapping disease genes, has recently been extended to the identification of quantitative trait loci (QTLs). A general TDT (TDTG) has been developed to ...
Molecular and Pharmacological Studies of Alpha1-AR Subtypes and their Signaling Pathways
(Creighton University, 2000-12)
Studies in part 1 of this dissertation were intended to develop selective inhibitors of (aiBAR and ajo-AR, respectively) subtype expression using antisense oligomer approaches. Using the nucleotide sequence of the (Xib-AR ...
Pneumolysin’s Role in Pneumococcal Clearance from the Bloodstream of the Alcohol-Ingesting Host
(Creighton University, 2000)
Alcoholism increases susceptibility to fatal infections caused by Streptococcus pneumoniae, or the pneumococcus (PNC). Alcoholics with PNC pneumonia have an increased likelihood of developing bacteremia, and alcohol ingestion ...
Electric Organ Discharge Frequency Modulations Evoked in Response to Jamming Stimuli in the Weakly Electric Brown Ghost Knifefish (Apteronotus Leptorynchus)
(Creighton University, 2000-09-20)
Gymnotiform electric fish emit a weak electric organ discharge (EOD) for the purpose of electrolocation. Although individual fish emit at unique EOD frequencies, they can actively modulate the frequency of their EODs during ...
Pharmacological Characterization of Prejunctional Serotonin Receptors in Mammalian Anterior Uvea
(Creighton University, 2000)
Serotonin (5-hydroxytiyptamine, 5-HT) and its receptors have been demonstrated in ocular tissues including the cornea, iris-ciliary body and retina of various species. The overall objective of the present study was two-fold: ...
Regulation of Vascular Smooth Muscle Cell Apoptosis by Insulin-like Growth Factor-1: Control of Apoptosis Induced by C-MYC and Protein Kinase Inhibition
(Creighton University, 2000-06-15)
The biological actions of insulin-like growth factor-1 (IGF-1) are critical from embryonic development through adulthood. IGF-1 exerts its actions almost exclusively through the IGF-1 receptor (IGF-1 R), perpetuating a ...
Modulation of Osteoblast Differentiation in Rat Calvarial Cells: Investigations into Effects of Mechanical Load and Interleukin-1β
(Creighton University, 2000-07)
The relationship between mechanical loading and adaptive changes in bony architecture was noted more than one hundred years ago, however, the mechanism of this process is still not understood. Effects of mechanical loading ...
Isolation, Structures, Synthesis and Biological Activities of Non-Mammalian Vertebrate Endothelins
(Creighton University, 2000)
The endothelins (ETs) are a family of peptides that have the most potent and long-lasting vasoconstrictivity yet described. They have been shown to exhibit a wide variety of pharmacological activities and may play diverse ...
Characterizing Deleterious Genomic Mutations in The Presence of Overdominance (a Computer Simulation Approach)
(Creighton University, 2000)
Most mutations with observable phenotypic effects are harmful. Characterizing Deleterious Genomic Mutations (DGMs) is essential in testing the numerous theories that have been developed to explain some fundamental biological ...