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Genetics Analysis of Bone Size Variation of Hip, Spine and Wrist in Human Pedigrees
(Creighton University, 2001-05)
Bone size is an important determinant of osteoporotic fracture. However, the importance of genetic factors in determining bone size variation is unknown. My purposes here are three-folded. 1) Estimate the heritability (h2) ...
A Genotypic Comparison of Staphylococcus lugdunensis Clinical Isolates of Diverse Geographic Origin
(Creighton University, 2001-04-24)
At the present time, little is known about the newly described coagulase negative staphylococcus, Staphylococcus lagdunensis. However, this organism has been associated with serious invasive infections and can easily be ...
Regulation of IL-13 by Histamine
(Creighton University, 2001)
According to the 1997 National Health Interview Study by the National Center for Health Statistics and the Center for Disease Control and Prevention, it was estimated that 25.7 million people had been diagnosed with asthma. ...
The Expression of the AmpC β-Lactamase of Serratia marcescens is Regulated at Multiple Levels
(Creighton University, 2001-04-30)
Serratia marcescens encodes an inducible, chromosomal beta-lactamase, ampC. ampC is inducible in S. marcescens and several other Gram-negative bacteria in the presence of different p- lactam antibiotics, and induction is ...
Investigation of The Role of Aromatic-Backbone Amide Interactions in Peptide and Protein Structure
(Creighton University, 2001)
The delicate balance of noncovalent interactions determines the three dimensional structure of peptides and proteins. These interactions include hydrogen bonds, salt bridges, weakly polar interactions and the hydrophobic ...
New Insights into the Mechanism of Alport Glomerular and Tubulointerstitial Pathogenesis
(Creighton University, 2001-12-10)
Alport syndrome is a hereditary disease that is manifested in the eyes, ears, and kidneys. Patients with Alport syndrome die of end-stage renal failure making the kidney the most critical of the affected organs. Using a ...
A Dual-GFP Reporter System for Studying Bi-Directional Promotion
(Creighton University, 2001)
Bi-directional promotion has been reported in various species. Understanding transcriptional control at these various loci requires a tool which measures bi-directional transcription. Green Fluorescent Protein (GFP) reporters ...
The Relationship of Discrete Amino Acid Regions to the Biochemical Properties of Human Phenol Sulfotransferases (SULTs)
(Creighton University, 2001)
Sulfation is important in the metabolism of many different compounds including phenols, monoamine neurotransmitters, steroid and thyroid hormones, and numerous xenobiotics. The addition of the sulfuryl moiety to substrates ...
Isolation and Characterization of Regulatory Peptides from Two Tetraploid Species, the Pallid Sturgeon, Scaphirhynchus albus, and the African Clawed Frog, Xenopus laevis
(Creighton University, 2001-07)
Tetraploidization, the duplication of the entire genome of an organism, results in twice the number of each gene present in the original diploid genome. Over time, the multiple copies of a single gene may accumulate different ...
Fibroblast Growth Factor Expression in Inner Correlates with Defects in the Null Mutant
(Creighton University, 2001-07-01)
The inner ear is a multifunctional organ required for hearing, balance, and proprioception of the head. Each area of sensory cells in the ear must develop to be perfectly situated to receive specific stimulation. Formally, ...