Microtubules are composed of heterodimers of a and ß tubulin. The main differences in amino acid sequence of the seven ß tubulin isotypes occur at the C- terminus, which has been implicated as a key player in microtubule ...

During embryonic development, cardiac neural crest {NC) cells arise from the dorsal portion of the neural tube through an epithelial-to-mesenchymal transition and then migrate into the pharyngeal arches and subsequently ...

Eosinophils are one of the major effector cells in asthma, and controlling the number and survival of eosinophils might attenuate the severity of asthma. This could be achieved by inducing eosinophil apoptosis. Apoptosis ...

Gene-encoded antimicrobial peptides are an important component of host defense in both invertebrates and vertebrates, ranging from insects to mammals. Although these peptides are usually isolated in high concentrations, ...

The Antarctic teleost Trematomus bemacchii lives in the waters surrounding Antarctica which are a constant -1.8°C. As an adaptive property they possess a uniquely high serum osmolality of -600 mOsm kg"1 which is nearly ...

The pineal hormone melatonin was extracted in 1958 from the bovine pineal gland. Ever since it has received vast popular attention as a hormone with beneficial effects on sleep disorders, jet lag and longevity. Recent ...

Aim - (from the introduction - no abstract provided) |The goal of this project is twofold. The primary goal is to improve our understanding of cochlear development, and the development of cochlear nonlinearity in particular. ...

The inner ear originates from an ectodermal thickening, the otic placode, which invaginates and forms the otic vesicle. The otic placode gives rise to the hearing (cochlea) and balance (vestibular) organs, comprising the ...

Human height is a highly heritable trait, with heritability generally above 0.75. Segregation analyses in different populations supported existence of major genes accounting for a considerable fraction of height variation. ...

Obesity is a condition of excess body fat that causes or exacerbates several major public health problems. Common obesity is a polygenic disorder arising from the interaction of multiple genetic and environmental factors. ...