Search
Now showing items 1-10 of 13
Role of Membrane-Type Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinase-2 in Neural Crest Cell Migration
(Creighton University, 2005)
During embryonic development, cardiac neural crest {NC) cells arise from the dorsal portion of the neural tube through an epithelial-to-mesenchymal transition and then migrate into the pharyngeal arches and subsequently ...
Effect of Smoke Exposure and Ethanol Ingestion on Anti-Pneumococcal Host Defenses
(Creighton University, 2005)
Alcohol abusers and smokers are more susceptible to the development of respiratory tract infections caused by Streptococcus pneumoniae, the pneumococcus.To investigate the effect of smoke exposure and EtOH ingestion on ...
Genome-wide Linkage Studies for Bone Mineral Density, Areal Bone Size, and Cross-sectional Bone Geometry
(Creighton University, 2005-05)
Osteoporosis is a major public health problem, mainly characterized by compromised bone strength. The bone strength is determined by many skeletal factors, including bone mineral density (BMD), geometric structure, ...
Requirement for the Isotype Specific C-terminus of ß Tubulin for Ciliary Function in Mammals
(Creighton University, 2005-05)
Microtubules are composed of heterodimers of a and ß tubulin. The main differences in amino acid sequence of the seven ß tubulin isotypes occur at the C- terminus, which has been implicated as a key player in microtubule ...
Genome-Wide Linkage Scan and Association Analyses for Obesity Genes
(Creighton University, 2005-08)
Obesity is a condition of excess body fat that causes or exacerbates several major public health problems. Common obesity is a polygenic disorder arising from the interaction of multiple genetic and environmental factors. ...
Regulation of STAT-1 Phosphorylation by Histamine Through H1 and H2 Receptors: Inverse Agonism and PKA-PKC Interaction in STAT-1 Phosphorylation
(Creighton University, 2005-05-05)
Signal transducer and activator of transcription-1 (STAT1) is a latent signal transducer protein which, on phosphorylation, is translocated from the cytoplasm to the nucleus and is subsequently activated. This work was ...
CD30: A Novel Receptor to Induce Apoptosis in Human Blood Eosinophils
(Creighton University, 2005-05)
Eosinophils are one of the major effector cells in asthma, and controlling the number and survival of eosinophils might attenuate the severity of asthma. This could be achieved by inducing eosinophil apoptosis. Apoptosis ...
Structural and Biological Characterization of Antimicrobial Peptides from Rana Sylvatica and Kassina Senegalensis
(Creighton University, 2005-03)
Gene-encoded antimicrobial peptides are an important component of host defense in both invertebrates and vertebrates, ranging from insects to mammals. Although these peptides are usually isolated in high concentrations, ...
Physiological, Biochemical, and Molecular Biological Effects of +4⁰C Acclimation on the Antarctic Teleost Trematomus bernacchii
(Creighton University, 2005)
The Antarctic teleost Trematomus bemacchii lives in the waters surrounding Antarctica which are a constant -1.8°C. As an adaptive property they possess a uniquely high serum osmolality of -600 mOsm kg"1 which is nearly ...
Cellular Mechanisms Underlying the Action of Melatonin in the Suprachiasmatic Nucleus
(Creighton University, 2005)
The pineal hormone melatonin was extracted in 1958 from the bovine pineal gland. Ever since it has received vast popular attention as a hormone with beneficial effects on sleep disorders, jet lag and longevity. Recent ...