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Correlation of Osteoporosis and Obesity
(Creighton University, 2006-08)
Osteoporosis and obesity are two complex diseases that are prevalent in the United States. Obesity is a condition of excess body fat that exacerbates several major public health problems. Osteoporosis is a skeletal disease ...
TRAIL and TGF-ßl-Induced Apoptosis of Human Airway Epithelial Cells
(Creighton University, 2006-07)
Asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness (AHR), airway obstruction, wheezing, and leads to airway remodeling if these symptoms persist. Airway remodeling is characterized by ...
Regulation of STAT6 and STAT4 Phosphorlation by Histamine
(Creighton University, 2006-11)
Signal transducer and activators of transcription (STAT) - 6 and STAT4 are the transcriptional factors crucial for the T helper cell differentiation into Thl and Th2 respectively. STAT6 is activated in response to IL-4 and ...
Multiplex PCR Assay for Detection of USA300 Community-Associated Methicillin-Resistant Staphylococcus aureus
(Creighton University, 2006-12-12)
Recent reports have noted a discernible increase in the number of community- associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections in patients without traditional risk factors. In the United States, ...
Design, Synthesis and Pharmacological Characterization of Novel Calcitonin Gene-Related Peptide Receptor Antagonists
(Creighton University, 2006-06)
ABSTRACT|Human-a-calcitonin gene-related peptide (CGRP) is a 37 amino acid residue neuropeptide produced from tissue-specific alternative splicing of the primary RNA transcript of the calcitonin gene. CGRP is widely ...
The Influence of ampC Expression and Penicillin Binding Protein Binding on the Variation of ß-lactam Induction Potential in Three Genera of Enterobacteriaceae
(Creighton University, 2006-04-08)
Citrobacter freundii, Enterobacter cloacae, and Serratia marcescens are members of the Enterobacteriaceae family and are significant nosocomial pathogens. These organisms encode inducible, chromosomal AmpC ß-lactamases ...
Anti-allergic drug and intracellular signaling mechanisms in human blood eosinophils and airway epithelial cells,
(Creighton University, 2006-04-25)
The atopic asthmatic response is very complex and involves various mediators, second messengers and cell types whose roles in the inflammatory response are being elucidated at the present time. Suplatast tosilate (IPD), a ...
A Mucoadhesives in Situ Gel Delivery System for Paclitaxel.
(Creighton University, 2006-08)
MUC1 gene encodes a transmembrane mucin glycoprotein that is over expressed in human breast cancer and colon cancer. The underlying hypothesis of this investigation was that a mucoadhesive in situ gel delivery system ...
Developmental Alterations in the Distribution of Specific Lateral Wall Proteins Modify Outer Hair Cell Mechanical Properties
(Creighton University, 2006-01)
In the mammalian cochlea, specialized outer hair cells (OHCs) housed within the organ of Corti exhibit nonlinear, mechanical responses to auditory stimulation [1]. These electromotile responses increase hearing sensitivity ...
Molecular Characterization of Fluoroquinolone Resistance in Streptococcus pneumoniae
(Creighton University, 2006-05-05)
Streptococcus pneumoniae is a leading cause of respiratory tract infections, meningitis, and acute otitis media. The emergence of S. pneumoniae strains with resistance to the ß-lactam and macrolide antibiotics has complicated ...