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Rarity of Novel microRNAs in the Mouse Inner Ear
(Creighton University, 2007-11)
The vertebrate inner ear is a complex organ that is highly regulated throughout development by molecular and cellular factors such as morphogens and transcription factors. Another class of gene regulators whose function ...
Preformulation and Formulation Development of a Novel Radioprotectant Drug
(Creighton University, 2007-10)
Onconova 1210.Na (1210) is a chlorobenzylsulfone derivative with potential property to mitigate the effects of accidental or intentional exposure to life threatening levels of radiation. A rapid and sensitive HPLC method ...
Identification, Characterization and Function of Voltage-Gated and Two-Pore-Domain Potassium Channels in the Mouse Myometrium.
(Creighton University, 2007)
I am interested in the contractility and electrical excitability in the uterus at the level of individual uterine myocytes throughout gestation. 1 believe by determining potential targets for functional changes in uterine ...
Genetic Linkage and Association Studies for Bone Geometry and Bone Mineral Density
(Creighton University, 2007-04)
Osteoporosis is a common skeletal disease becoming one of the biggest public health menaces with the consequence of millions of fractures annually around the world. Osteoporosis is mainly characterized by compromised bone ...
Improvements in Upper Limits of the Neutralino-Proton Cross Section through use of Model-Independent Nuclear Form Factors.
(Creighton University, 2007-07-11)
Theoretical calculations of neutralino cross sections with various nuclei are of great interest to direct dark matter searches such as CDMS, EDELWEISS, ZEPLIN, and other experiments. These cross sections and direct detection ...
In vivo Genome-wide Expression Study on Human Blood B cells Suggests a Novel ESRI and MAPK3 Network for Postmenopausal Osteoporosis
(Creighton University, 2007-05)
Osteoporosis is characterized by low BMD resulting from bone resorption (by osteoclasts) exceeding bone formation (by osteoblasts). In postmenopausal women, estrogen deficiency evokes increased osteoclastic activity and ...
The Challenge of Modifying Deviant Behavior: Restructuring Incentives in Renegade Regimes
(Creighton University, 2007-08-23)
This thesis considers whether international coercion used to confront deviant behavior in renegade or rogue regimes produces an offset of the benefits of continued defiant behavior, or produces a restructuring of incentives ...
Zenith Angle Dependence of Prompt Muons in High Energy Cosmic Showers
(Creighton University, 2007-08)
The prompt component of cosmic showers received increasing interest in the last decade because of its potential to expose us to new physics and to help us explore the universe using neutrino telescopes. In this study we ...
Business or Pleasure? Examining the Reasons Behind China's African Venture
(Creighton University, 2007-09)
The last decade has witnessed a marked increase in Chinese activity in Africa, characterized by an explosion in bilateral trade, investment, bilateral leadership visits and the commitment of Chinese peacekeeping troops to ...
Genomic Conservation of the Outer Hair Cell Motility Protein, Prestin in the Monotreme: Ornithorhyncus anatinus (Platypus)
(Creighton University, 2007-08)
The process of outer hair cell (OHC) motility, which enables sound amplification, is an active process that is thought to be unique to mammals. Prestin, the motor protein of these OHCs, is crucial for its function in ...