Now showing items 1-4 of 4
Regulation of STAT-1 Phosphorylation by Histamine Through H1 and H2 Receptors: Inverse Agonism and PKA-PKC Interaction in STAT-1 Phosphorylation
(Creighton University, 2005-05-05)
Signal transducer and activator of transcription-1 (STAT1) is a latent signal transducer protein which, on phosphorylation, is translocated from the cytoplasm to the nucleus and is subsequently activated. This work was ...
Expression of Suppressors of Cytokine Signaling Proteins in Airway Epithelial Cells
(Creighton University, 2007-07)
Since their discovery, Suppressors of Cytokine Signaling, or SOCS proteins, have been found in numerous cell types, but their role in asthma is not completely clear. Although the exact mechanisms are unclear and interpretations ...
Mycobacterial Antigens and Immunomodulation in Allergic Asthma
(Creighton University, 2003-02)
The disease asthma is characterized by the hallmark features of airway hyperresponsiveness (AHR), increased serum concentrations of IgE and type 2 cytokines, and tissue and bronchoalveolar lavage (BAL) eosinophilia. It has ...
Regulation of STAT6 and STAT4 Phosphorlation by Histamine
(Creighton University, 2006-11)
Signal transducer and activators of transcription (STAT) - 6 and STAT4 are the transcriptional factors crucial for the T helper cell differentiation into Thl and Th2 respectively. STAT6 is activated in response to IL-4 and ...