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Robustness And Power of a TDT Statistic for Mapping Quantitative Trait Loci
(Creighton University, 2000-08)
The transmission disequilibrium test (TDT), originally developed for mapping disease genes, has recently been extended to the identification of quantitative trait loci (QTLs). A general TDT (TDTG) has been developed to ...
Characterizing Deleterious Genomic Mutations in Simulated Populations Under Some Biologically Realistic Situations
(Creighton University, 2000)
The DENG-LYNCH method was developed to estimate the rate and effects of deleterious genomic mutations (DGM) in natural populations under the assumptions that populations are infinite with unlinked loci, completely outcrossing ...
Characterizing Deleterious Genomic Mutations in The Presence of Overdominance (a Computer Simulation Approach)
(Creighton University, 2000)
Most mutations with observable phenotypic effects are harmful. Characterizing Deleterious Genomic Mutations (DGMs) is essential in testing the numerous theories that have been developed to explain some fundamental biological ...