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Pharmacological Studies of the Signal Transduction Pathways of the a 1a-Adrenbrgic Receptor Subtype
(Creighton University, 2003-05)
Alpha 1-adrenergic receptors (a1-ARs) are a heterogeneous group of G protein- coupled seven transmembrane receptors that mediate the actions of the endogenous catecholamines, norepinephrine and epinephrine. Three 1a-AR ...
A Molecular and Pharmacological Study of the α1- Adregenergic Receptors: From the Novel Alternatively Spliced α1A-AR Isoforms to the Acute Effects of the Triiodothyronine
(Creighton University, 2002-12-06)
Numerous literary works dating as far back as the turn of the 19th century contain precise physiological descriptions of adrenergic stimulatory effects on the human body, which offer testimony to our interest in adrenergic ...
Molecular and Pharmacological Studies of Alpha1-AR Subtypes and their Signaling Pathways
(Creighton University, 2000-12)
Studies in part 1 of this dissertation were intended to develop selective inhibitors of (aiBAR and ajo-AR, respectively) subtype expression using antisense oligomer approaches. Using the nucleotide sequence of the (Xib-AR ...
Pharmacological Studies Of Alpha-1 Adrenergic Receptors
(Creighton University, 2004-06)
Recently an immortalized epithelial ceil line, SMG-C10, was isolated from rat submandibular gland cells. We compared the pharmacological characteristics of ar AR in SMG-C10 cells using [125I]BE 2254. The subtype-selective ...