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MicroRNAs are essential for hair cell development.
(Creighton University, 2008-10-10)
MicroRNAs are small non-coding RNAs that are processed through an endogenous biological pathway and function to post-transcriptionally regulate target gene expression. MicroRNAs affect cellular proliferation, differentiation, ...
Development and Characterization of Nanoparticulate Delivery System for the Radioprotectant Drug Amifostine
(Creighton University, 2008-05)
Amifostine is a cytoprotectant drug used as an adjunct in cancer chemotherapy and radiation therapy. A simple and sensitive HPLC method was developed and validated for the assay of Amifostine. The method consisted of 95:5 ...
The Effects of Chronic Ethanol Ingestion and Smoke Exposure on Anti-Pneumococcal Host Defenses
(Creighton University, 2008-12)
Individuals who abuse alcohol and tobacco are at increased risk for pneumonia caused by Streptococcus pneumoniae (the pneumococcus). Alcohol and cigarette smoke are known to exert immunosuppressive effects on pulmonary ...
Hybrid Ray Optics and Continuum Mechanics Modeling of Cell Deformation in the Optical Stretcher
(Creighton University, 2008-01-21)
Since the invention of the optical stretcher in 2001, no direct method has been found for measuring the optical stress that produces the observed trapping and stretching of biological cells and other dielectrics. Hence, ...
TGF-β1-induced Chloride Channel Activity and Migration of Human Eosinophils
(Creighton University, 2009-05)
Asthma is a chronic disease of the airways characterized by airway hyperresponsiveness, airway inflammation, and airway remodeling. Eosinophils migrate to the airways and play a significant role in the pathogenesis of ...
A Study of the Causal Factors of Civil War in the 1990s
(Creighton University, 2009-07-14)
In recent decades there has been a rise in intrastate conflicts. This thesis explores the causes of civil war, focusing on ethnic, religious, institutional and economic factors contributing to or alleviating internal ...
Political Effects of Remittances: Political Participation in Developing Countries
(Creighton University, 2008-12-04)
In this thesis I propose to analyze the effects of remittances on political participation in the recipient countries. I test two opposing hypotheses. The first hypothesis argues that dependence on remittances results in a ...
TH17 Cells and Suppressor of Cytokine Signaling in House Dust Mite Model of Asthma: Effect of by FLT-3 Ligand
(Creighton University, 2009-04-06)
Asthma is a chronic inflammatory disorder of the airways. In this disease an allergic reaction occurs that shifts T-helper (Th) cells towards a Th2 subtype response to innocuous antigen characterized by a predominant ...
Successful Women Leaders in the Workplace: Advice to Fill a Briefcase for Success
(Creighton University, 2009-01-13)
This thesis addresses the following research question: what are the steps a young professional woman can take right now-this minute-in order to achieve organizational leadership and success in Omaha, Nebraska in the near ...
STARlight: A C++ Object-Oriented Monte Carlo Event Generator for Ultra-Peripheral Collisions
(Creighton University, 2009-12-25)
Ultra-peripheral collisions occur when nuclei pass one another without overlapping. The intense electric fields present can be treated as a flux of virtual photons; these photons can interact with the other nucleus or each ...