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CD30: A Novel Receptor to Induce Apoptosis in Human Blood Eosinophils
(Creighton University, 2005-05)
Eosinophils are one of the major effector cells in asthma, and controlling the number and survival of eosinophils might attenuate the severity of asthma. This could be achieved by inducing eosinophil apoptosis. Apoptosis ...
Physiological, Biochemical, and Molecular Biological Effects of +4⁰C Acclimation on the Antarctic Teleost Trematomus bernacchii
(Creighton University, 2005)
The Antarctic teleost Trematomus bemacchii lives in the waters surrounding Antarctica which are a constant -1.8°C. As an adaptive property they possess a uniquely high serum osmolality of -600 mOsm kg"1 which is nearly ...
Preformulation and Formulation Development of a Novel Radioprotectant Drug
(Creighton University, 2007-10)
Onconova 1210.Na (1210) is a chlorobenzylsulfone derivative with potential property to mitigate the effects of accidental or intentional exposure to life threatening levels of radiation. A rapid and sensitive HPLC method ...
In Vitro Evaluation of Antiemetic Topical Gels in Cancer Chemotherapy
(Creighton University, 2007-08)
The objective of this study was to evaluate the diffusivity and the release characteristics of different antiemetics from plurionic gels using various in vitro models (polymeric membrane, skin sheds of Yellow Rat and Com ...
Cellular Mechanisms Underlying the Action of Melatonin in the Suprachiasmatic Nucleus
(Creighton University, 2005)
The pineal hormone melatonin was extracted in 1958 from the bovine pineal gland. Ever since it has received vast popular attention as a hormone with beneficial effects on sleep disorders, jet lag and longevity. Recent ...
Angiotensin II-induced Apoptosis in Vascular Smooth Muscle Cells: Differential Effects in Human Saphenous Vein and Human Internal Mammary Artery
(Creighton University, 2006-08)
Coronary artery bypass grafting serves as a viable treatment for arterial vascular occlusions. However, the likelihood for developing restenosis following coronary artery bypass grafting surgery remains a major threat. ...
The Structural and Physiological Effects of -1.5°C, +4°C and +1°C Acclimation on the Antarctic Teleost Trematomus bernacchii
(Creighton University, 2007-12)
The Antarctic teleost Trematomus bernacchii lives in a saltwater environment with an average temperature of -1.8°C. These fish possess several unique adaptations including a serum osmolality that is nearly double that of ...
Anti-allergic drug and intracellular signaling mechanisms in human blood eosinophils and airway epithelial cells,
(Creighton University, 2006-04-25)
The atopic asthmatic response is very complex and involves various mediators, second messengers and cell types whose roles in the inflammatory response are being elucidated at the present time. Suplatast tosilate (IPD), a ...
Genetic Linkage to Human Height is Identified to 9q22 and Xq24
(Creighton University, 2005-07)
Human height is a highly heritable trait, with heritability generally above 0.75. Segregation analyses in different populations supported existence of major genes accounting for a considerable fraction of height variation. ...
The Role of Erbb2 in Ultraviolet-Induced Nonmelanoma Skin Carcinogenesis
(Creighton University, 2006-06)
Significance (from the introduction - no abstract provided)|Nonmelanoma skin cancer is more common than all other forms of cancer combined and its incidence is increasing. Most of these cancers are caused by UV, which has ...