Search
Now showing items 111-120 of 162
Clinical and Molecular Characterization of Auditory Neuropathy
(Creighton University, 2003)
Auditory Neuropathy (AN) is diagnosed when the auditory brainstem response (ABR) is absent and outer hair cells (OHC) function normally, which indicates that the lesion lies in the inner hair cells (IHC), their afferent ...
Regulation of blaFOX-5b Expression Within Two Different Genetic Backgrounds: Klebsiella pneumoniae and Escherichia coli
(Creighton University, 2003-09-26)
Klebsiella pneumoniae and Escherichia coli are major nosocomial pathogens. A clinical isolate of K.pneumoniae and E. coli were found to produce a novel plasmid-encoded ampC P-lactamase gene, blaFOX-5b- These isolates ...
Angular Correlation of Emitted Neutrons Due to Giant Dipole Resonance in Ultra Peripheral Collisions
(Creighton University, 2008-05-29)
In an ultra peripheral collision with two gold ions, two virtual photons are exchanged, which excites the nuclei into a mutual giant dipole resonance (GDR) state. This excited state decays most often via neutron emission. ...
The Effects of Chronic Ethanol Ingestion and Smoke Exposure on Anti-Pneumococcal Host Defenses
(Creighton University, 2008-12)
Individuals who abuse alcohol and tobacco are at increased risk for pneumonia caused by Streptococcus pneumoniae (the pneumococcus). Alcohol and cigarette smoke are known to exert immunosuppressive effects on pulmonary ...
Effects of Homocysteine on Cardiac Neural Crest Cell Formation
(Creighton University, 2002)
Elevated homocysteine (Hcys) causes a wide spectrum of congenital detects, many of which resemble neural crest (NC) cell ablation. However, the etiological mechanism is not known. The purpose of this study was to determine ...
Detection of Plasmid-Mediated AmpC b-Lactamases
(Creighton University, 2004-07)
Although plasmid-mediated AmpC b-lactamases were first reported in the late 1980's, most clinical laboratories and physicians remain unaware of their clinical importance. Current detection methods for organisms producing ...
Assessment of Vl30 Erythropoietin Responsive Promoters for Erthyroid Gene Therapy
(Creighton University, 2002-06)
Congenital blood disorders such as hemoglobinopathies and thalassemias are common, and yet clinically challenging glob in disorders. Gene therapy was thought to serve as a therapeutic method to treat these disorders through ...
Cloning and Tissue Distribution of Two NA+/H+ Exchangers from the Malpighian Tubules of Aedes Aegypti
(Creighton University, 2002)
A Na+/H+ exchanger (NHE) on the apical membrane of mosquito Malpighian tubule (MT) cells likely participates in the female blood-feeding mosquito's necessary secretion ofNa+ and fluid. This study presents the molecular ...
Upregulation of PIP3-dependent RAC Exchanger 1 (P-Rex1) Promotes Prostate Cancer Metastasis
(Creighton University, 2008-08-18)
Activation of Rac by guanine-nucleotide exchange factors (GEFs) at the leading edge of the cell plays an important role in directional cell migration, a critical step of tumor metastasis cascades. We investigated the role ...
MicroRNAs are essential for hair cell development.
(Creighton University, 2008-10-10)
MicroRNAs are small non-coding RNAs that are processed through an endogenous biological pathway and function to post-transcriptionally regulate target gene expression. MicroRNAs affect cellular proliferation, differentiation, ...