Now showing items 121-130 of 162
Hybrid Ray Optics and Continuum Mechanics Modeling of Cell Deformation in the Optical Stretcher
(Creighton University, 2008-01-21)
Since the invention of the optical stretcher in 2001, no direct method has been found for measuring the optical stress that produces the observed trapping and stretching of biological cells and other dielectrics. Hence, ...
Constructing Minority Governments
(Creighton University, 2008-09-25)
TGF-β1-induced Chloride Channel Activity and Migration of Human Eosinophils
(Creighton University, 2009-05)
Asthma is a chronic disease of the airways characterized by airway hyperresponsiveness, airway inflammation, and airway remodeling. Eosinophils migrate to the airways and play a significant role in the pathogenesis of ...
A Study of the Causal Factors of Civil War in the 1990s
(Creighton University, 2009-07-14)
In recent decades there has been a rise in intrastate conflicts. This thesis explores the causes of civil war, focusing on ethnic, religious, institutional and economic factors contributing to or alleviating internal ...
Development and Characterization of Nanoparticulate Delivery System for the Radioprotectant Drug Amifostine
(Creighton University, 2008-05)
Amifostine is a cytoprotectant drug used as an adjunct in cancer chemotherapy and radiation therapy. A simple and sensitive HPLC method was developed and validated for the assay of Amifostine. The method consisted of 95:5 ...
Molecular Characterization of Fluoroquinolone Resistance in Streptococcus pneumoniae
(Creighton University, 2006-05-05)
Streptococcus pneumoniae is a leading cause of respiratory tract infections, meningitis, and acute otitis media. The emergence of S. pneumoniae strains with resistance to the ß-lactam and macrolide antibiotics has complicated ...
Design, Synthesis and Pharmacological Characterization of Novel Calcitonin Gene-Related Peptide Receptor Antagonists
(Creighton University, 2006-06)
ABSTRACT|Human-a-calcitonin gene-related peptide (CGRP) is a 37 amino acid residue neuropeptide produced from tissue-specific alternative splicing of the primary RNA transcript of the calcitonin gene. CGRP is widely ...
The Influence of ampC Expression and Penicillin Binding Protein Binding on the Variation of ß-lactam Induction Potential in Three Genera of Enterobacteriaceae
(Creighton University, 2006-04-08)
Citrobacter freundii, Enterobacter cloacae, and Serratia marcescens are members of the Enterobacteriaceae family and are significant nosocomial pathogens. These organisms encode inducible, chromosomal AmpC ß-lactamases ...
Genome-Wide Linkage Scan and Association Analyses for Obesity Genes
(Creighton University, 2005-08)
Obesity is a condition of excess body fat that causes or exacerbates several major public health problems. Common obesity is a polygenic disorder arising from the interaction of multiple genetic and environmental factors. ...
Regulation of STAT-1 Phosphorylation by Histamine Through H1 and H2 Receptors: Inverse Agonism and PKA-PKC Interaction in STAT-1 Phosphorylation
(Creighton University, 2005-05-05)
Signal transducer and activator of transcription-1 (STAT1) is a latent signal transducer protein which, on phosphorylation, is translocated from the cytoplasm to the nucleus and is subsequently activated. This work was ...