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Now showing items 121-130 of 162
Mechanisms of Epidermal Growth Factor Receptor Regulation of Epidermal Proliferation and Skin Tumorigenesis in Response to Ultraviolet Irradiation.
(Creighton University, 2004-08)
The epidermal growth factor receptor (EGFR), a receptor tyrosine kinase, regulates both skin biology and carcinogenesis. We hypothesized that EGFR-dependent signal transduction increases normal keratinocyte proliferation ...
Genome-wide Linkage Studies for Bone Mineral Density, Areal Bone Size, and Cross-sectional Bone Geometry
(Creighton University, 2005-05)
Osteoporosis is a major public health problem, mainly characterized by compromised bone strength. The bone strength is determined by many skeletal factors, including bone mineral density (BMD), geometric structure, ...
Cholecystokinin Action at CCK1 Receptors in the Brain to Produce Satiety in Rats
(Creighton University, 2001)
Cholecystokinin (CCK) is a peptide that is found throughout the brain and in neurons and endocrine cells of the gastrointestinal tract. Studies demonstrating that systemic administration of the CCK1 receptor antagonist ...
A Pharmacological Study of Calcitonin Gene-related Peptide Receptor Subtypes
(Creighton University, 2002-05)
Calcitonin gene-related peptide (CGRP) receptors are divided into CGRP1 and CGRP2 receptor subtypes based on their affinity for CGRP8-37 in functional assays. CGRP1 receptors are blocked with high affinity (Kb < 100 nM) ...
Pharmacological Studies of Histamine Receptors in the Anterior Uvea
(Creighton University, 2002)
Although histamine has been localized in ocular tissues, its role in aqueous humor dynamics and the regulation of intraocular pressure (IOP) is yet to be fully determined. The overall objective of the present study was ...
Effect of Smoke Exposure and Ethanol Ingestion on Anti-Pneumococcal Host Defenses
(Creighton University, 2005)
Alcohol abusers and smokers are more susceptible to the development of respiratory tract infections caused by Streptococcus pneumoniae, the pneumococcus.To investigate the effect of smoke exposure and EtOH ingestion on ...
Immunomodulation of Allergic Airway Inflammation by FLT3-ligand
(Creighton University, 2004-12)
Allergic asthma is a chronic disease of the lungs associated with bronchoconstriction, increased type 2 (Th2) cytokines interleukin (IL-) 4, IL-5, IL-13, eosinophilia, and chronic inflammation in the airways. There has ...
Sequence-Based Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus
(Creighton University, 2003-12-12)
Methicillin-resistant S. aureus (MRSA) are a major cause of nosocomial infections requiring accurate and rapid molecular techniques for epidemiological analysis. Increased genomic sequence information has resulted in the ...
Characterization of Usher Syndrome Type 1 Heterogeneity by Genetic and Phenotypic Analyses
(Creighton University, 2002)
Patients with Usher syndrome type I suffer from sensorineural hearing impairment, retinal degeneration and often, vestibular dysfunction. Significant genetic heterogeneity exists as seven different genes are currently ...
Parathyroid Hormone-Related Peptide Immunolocalization During Early Chick Cardiac Development
(Creighton University, 2000)
Parathyroid hormone-related peptide (PTHrP) has been implicated in mediating proliferation and differentiation in various tissues in the developing embryo but its role in early heart development has not been investigated. ...