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Now showing items 131-140 of 162
Molecular Cloning and General Characterization of Human Estrogen Receptor-alpha 36 (ERa36) Gene Promoter
(Creighton University, 2006)
Estrogen receptor-alpha (ERa) mediates diverse estrogen functions through transactivation of target gene expression and the membrane-associated signaling pathways. Recently, we identified and cloned a novel variant of ERa, ...
The Expression of the AmpC β-Lactamase of Serratia marcescens is Regulated at Multiple Levels
(Creighton University, 2001-04-30)
Serratia marcescens encodes an inducible, chromosomal beta-lactamase, ampC. ampC is inducible in S. marcescens and several other Gram-negative bacteria in the presence of different p- lactam antibiotics, and induction is ...
Regulation of IGF-i Signaling by SOCS3 in Human Coronary Artery Smooth Muscle Cells
(Creighton University, 2007-01)
Plaque disruption with superimposed thrombosis is the main cause of unstable angina, myocardial infarction and sudden death. Instability of a plaque depends on the balance between release of extracellular matrix by human ...
Molecular Mechanisms of Growth Inhibition Mediated by Retinoic Acid in Human Pancreatic Cancer Cells
(Creighton University, 2004)
Pancreatic cancer is a deadly disease and is the fourth leading cause of cancer deaths in the United States. It is characterized by poor prognosis, metastasis at the time of diagnosis and lack of response to conventional ...
Development of the Inner Ear: a Molecular, Cellular and Evolutionary Approach to Understanding the Development of the Inner Ear with an Emphasis on the Roles of Fgf10 and Foxgl
(Creighton University, 2006)
(First paragraph) Hearing loss is a condition affecting people of all ages and can be categorized as either conductive or sensorineural. Conductive hearing loss is caused by pathology of the middle ear and will not be ...
Investigation of The Role of Aromatic-Backbone Amide Interactions in Peptide and Protein Structure
(Creighton University, 2001)
The delicate balance of noncovalent interactions determines the three dimensional structure of peptides and proteins. These interactions include hydrogen bonds, salt bridges, weakly polar interactions and the hydrophobic ...
Isolation, Structures, Synthesis and Biological Activities of Non-Mammalian Vertebrate Endothelins
(Creighton University, 2000)
The endothelins (ETs) are a family of peptides that have the most potent and long-lasting vasoconstrictivity yet described. They have been shown to exhibit a wide variety of pharmacological activities and may play diverse ...
New Insights into the Mechanism of Alport Glomerular and Tubulointerstitial Pathogenesis
(Creighton University, 2001-12-10)
Alport syndrome is a hereditary disease that is manifested in the eyes, ears, and kidneys. Patients with Alport syndrome die of end-stage renal failure making the kidney the most critical of the affected organs. Using a ...
Chitosan-hydroxyapatite Drug Delivery System in Root Canal Filling and Delivery
(Creighton University, 2007-01)
A root canal is one of the major components of a tooth. It is a long passage full of soft tissues, deep within thg, dentin of the tooth, adjoining the pulp chamber. The major cause of root canal infection is endodontic ...
Characterizing Deleterious Genomic Mutations in Simulated Populations Under Some Biologically Realistic Situations
(Creighton University, 2000)
The DENG-LYNCH method was developed to estimate the rate and effects of deleterious genomic mutations (DGM) in natural populations under the assumptions that populations are infinite with unlinked loci, completely outcrossing ...