Introduction Immune repertoire diversity is largely achieved by a process termed V(D)J recombination, during which functional antigen receptor genes are assembled from discrete gene segments through site-specific DNA ...

Gemcitabine is a nucleoside analogue, used in various carcinomas such as non small cell lung cancer, pancreatic cancer, ovarian cancer and breast cancer. The major setbacks to the conventional therapy with gemcitabine ...

The early events of human immunodeficiency virus type 1 (HIV-1) infection are mediated by two large nucleoprotein complexes (NPCs), the reverse transcription complex (RTC) and the preintegration complex (PIC). These ...

Asthma is a chronic disease of the airways, characterized by airway hyper-responsiveness (AHR) and airway inflammation. Many inflammatory cells, including mast cells, eosinophils, neutrophils, and lymphocytes, are critical ...

Alcohol abusers and smokers are more susceptible to the development of respiratory tract infections caused by Streptococcus pneumoniae, the pneumococcus.To investigate the effect of smoke exposure and EtOH ingestion on ...

Pancreatic carcinoma is characterized by a poor prognosis and lack of response to conventional therapy. The incidence of this disease shows no sign of declining. Tins disease is now the fifth leading cause of cancer death ...

Allergic asthma is a chronic disease of the lungs associated with bronchoconstriction, increased type 2 (Th2) cytokines interleukin (IL-) 4, IL-5, IL-13, eosinophilia, and chronic inflammation in the airways. There has ...

Cholecystokinin (CCK) is a peptide that is found throughout the brain and in neurons and endocrine cells of the gastrointestinal tract. Studies demonstrating that systemic administration of the CCK1 receptor antagonist ...

Structural requirements for binding of gastrin to the human CCK2 receptor and the existence of receptors for gastrin peptides on human colon cancer cells were investigated. CCK2 receptor studies focused on the importance ...