Now showing items 131-140 of 162
Sequence and Structure Specific Cleavage of Cryptic Recombination Signal Sequences by the V(D)J Recombinase
(Creighton University, 2009-12)
Introduction Immune repertoire diversity is largely achieved by a process termed V(D)J recombination, during which functional antigen receptor genes are assembled from discrete gene segments through site-specific DNA ...
Development and Characterization of Polymeric Nanoparticulate Delivery System for Hydrophillic Drug: Gemcitabine.
(Creighton University, 2009-12)
Gemcitabine is a nucleoside analogue, used in various carcinomas such as non small cell lung cancer, pancreatic cancer, ovarian cancer and breast cancer. The major setbacks to the conventional therapy with gemcitabine ...
Purification of Human Immunodeficiency Virus Type 1 Preintegration Complexes by Velocity Gradient Centrifugation.
(Creighton University, 2009-12-11)
The early events of human immunodeficiency virus type 1 (HIV-1) infection are mediated by two large nucleoprotein complexes (NPCs), the reverse transcription complex (RTC) and the preintegration complex (PIC). These ...
T-Regulatory Cells and FLT3-Ligand in the Therapy of Cockroach Antigen-induced Asthma
(Creighton University, 2009-05)
Asthma is a chronic disease of the airways, characterized by airway hyper-responsiveness (AHR) and airway inflammation. Many inflammatory cells, including mast cells, eosinophils, neutrophils, and lymphocytes, are critical ...
How to Die Young in Nebraska - Stories
(Creighton University, 2008-05-01)
Effect of Smoke Exposure and Ethanol Ingestion on Anti-Pneumococcal Host Defenses
(Creighton University, 2005)
Alcohol abusers and smokers are more susceptible to the development of respiratory tract infections caused by Streptococcus pneumoniae, the pneumococcus.To investigate the effect of smoke exposure and EtOH ingestion on ...
Regulation of Pancreatic Cancer Cell Proliferation Via the 5~Lipoxygenase Pathway
(Creighton University, 2001-06)
Pancreatic carcinoma is characterized by a poor prognosis and lack of response to conventional therapy. The incidence of this disease shows no sign of declining. Tins disease is now the fifth leading cause of cancer death ...
Immunomodulation of Allergic Airway Inflammation by FLT3-ligand
(Creighton University, 2004-12)
Allergic asthma is a chronic disease of the lungs associated with bronchoconstriction, increased type 2 (Th2) cytokines interleukin (IL-) 4, IL-5, IL-13, eosinophilia, and chronic inflammation in the airways. There has ...
Cholecystokinin Action at CCK1 Receptors in the Brain to Produce Satiety in Rats
(Creighton University, 2001)
Cholecystokinin (CCK) is a peptide that is found throughout the brain and in neurons and endocrine cells of the gastrointestinal tract. Studies demonstrating that systemic administration of the CCK1 receptor antagonist ...
The Structural Requirements of Gastrin and Glycine-Extended Gastrin for Binding to Receptors from Normal and Cancerous Human Tissues
(Creighton University, 2004-05-13)
Structural requirements for binding of gastrin to the human CCK2 receptor and the existence of receptors for gastrin peptides on human colon cancer cells were investigated. CCK2 receptor studies focused on the importance ...