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Rarity of Novel microRNAs in the Mouse Inner Ear
(Creighton University, 2007-11)
The vertebrate inner ear is a complex organ that is highly regulated throughout development by molecular and cellular factors such as morphogens and transcription factors. Another class of gene regulators whose function ...
CD30: A Novel Receptor to Induce Apoptosis in Human Blood Eosinophils
(Creighton University, 2005-05)
Eosinophils are one of the major effector cells in asthma, and controlling the number and survival of eosinophils might attenuate the severity of asthma. This could be achieved by inducing eosinophil apoptosis. Apoptosis ...
Generation and analysis of transgenetic mice expressing catalytically inactive recombination activating gene-1
(Creighton University, 2006-05)
The proteins encoded by the recombination activating genes (RAG1 and RAG2) are lymphoid cell-specific endonucleases that initiate V(D)J recombination; the mechanism by which the exons that encode the variable portion of ...
A Mucoadhesives in Situ Gel Delivery System for Paclitaxel.
(Creighton University, 2006-08)
MUC1 gene encodes a transmembrane mucin glycoprotein that is over expressed in human breast cancer and colon cancer. The underlying hypothesis of this investigation was that a mucoadhesive in situ gel delivery system ...
TRAIL and TGF-ßl-Induced Apoptosis of Human Airway Epithelial Cells
(Creighton University, 2006-07)
Asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness (AHR), airway obstruction, wheezing, and leads to airway remodeling if these symptoms persist. Airway remodeling is characterized by ...
Multiplex PCR Assay for Detection of USA300 Community-Associated Methicillin-Resistant Staphylococcus aureus
(Creighton University, 2006-12-12)
Recent reports have noted a discernible increase in the number of community- associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections in patients without traditional risk factors. In the United States, ...
The V(D)J Recombinase: Toward A Mechanistic Understanding Of Its Cleavage Activity
(Creighton University, 2008-06-10)
Introduction. V(D)J recombination is a form of site-specific DNA rearrangement that is responsible for assembling antigen receptor genes during lymphocyte development. This process is initiated when two lymphoid cell ...
Identification, Characterization and Function of Voltage-Gated and Two-Pore-Domain Potassium Channels in the Mouse Myometrium.
(Creighton University, 2007)
I am interested in the contractility and electrical excitability in the uterus at the level of individual uterine myocytes throughout gestation. 1 believe by determining potential targets for functional changes in uterine ...
Correlation of Osteoporosis and Obesity
(Creighton University, 2006-08)
Osteoporosis and obesity are two complex diseases that are prevalent in the United States. Obesity is a condition of excess body fat that exacerbates several major public health problems. Osteoporosis is a skeletal disease ...
Structural and Biological Characterization of Antimicrobial Peptides from Rana Sylvatica and Kassina Senegalensis
(Creighton University, 2005-03)
Gene-encoded antimicrobial peptides are an important component of host defense in both invertebrates and vertebrates, ranging from insects to mammals. Although these peptides are usually isolated in high concentrations, ...