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dc.contributor.authorUrick, Andrew
dc.contributor.authorKum, John
dc.contributor.authorHulce, Martin
dc.date.accessioned2012-04-11T03:25:43Z
dc.date.available2012-04-11T03:25:43Z
dc.date.issued2012-03-28
dc.identifier.urihttp://hdl.handle.net/10504/27820
dc.description.abstractExocyclic allenes are well represented among allenecontaining natural products, such as the grasshopper ketone. Allenes have been demonstrated in certain circumstances to embody similar properties to alkynes, and consequently have shown potential as alternative functional groups to be utilized as molecular scaffolds for pharmaceutical development. Commonly syntheses of exocyclic allenes rely on extended conjugate additions, or SN2-like alkylations and reductions of alkynyl epoxides.1 We report rapid synthesis of exocyclic allenes with 2 molar equivalents of lithium aluminum hydride in reduction of a vinylogously propargylic intermediate alcoholate with an attached trimethylsilyl group,2,3 thus providing a new, potentially general, method for their preparation.en_US
dc.publisherCreighton Universityen_US
dc.subject.lcshReaction mechanisms (Chemistry)en_US
dc.subject.lcshAllenesen_US
dc.subject.lcshSynthesisen_US
dc.titleSynthesis of Exocyclic Allenes by Double Reduction with Lithium Aluminum Hydrideen_US
dc.typeGenericen_US
dc.rights.holderAndrew Uricken_US
dc.rights.holderJohn Kumen_US
dc.rights.holderMartin Hulceen_US
dc.program.unitChemistryen_US
dc.contributor.cuauthorUrick, Andrew
dc.contributor.cuauthorKum, John
dc.contributor.cuauthorHulce, Martin


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