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dc.contributor.advisorGross, Stephen M.en_US
dc.contributor.authorFalbo, Michelleen_US
dc.date.accessioned2012-05-15T16:24:39Z
dc.date.available2014-05-15T08:40:06Z
dc.date.issued2012-04-04en_US
dc.identifier.otherFalbo FINAL THESIS1.pdf
dc.identifier.urihttp://hdl.handle.net/10504/28681
dc.description.abstractThe prevention of caries continues to remain a prominent concern among dental professionals. Although products such as toothpaste, mouthwash, and sealants have all targeted this process, the challenge against primary and secondary caries still persists. This study provided a distinctive approach by creating a ubiquitous platform capable of being incorporated into several types of dentrifices. Calcium, fluoride, and phosphate salts already solvated were encapsulated and loaded into a rosin varnish. This approach was unique because it had the potential for providing bioavailable ions for remineralization. By altering certain variables, it was determined that the ions studied in this experiment were capable of diffusing from the microcapsule and through the rosin varnish in a bioavailable form. The microcapsule polymer type was found to have an effect on the rate of phosphate ion release. When analyzing the release of the three ion types, phosphate released the fastest, followed by calcium and fluoride. When comparing different loaded weight percents of microcapsules, the 3 w/w%, 9 w/w%, and 15 w/w% loaded formulations, the 15 w/w% formulation released phosphate ions the fastest, followed by the 9 w/w% and 3 w/w% formulations. The 30 w/w% and 50 w/w% loaded microcapsules released phosphate ions slower initially. Phosphate ion release profiles varied when altering the concentration of the salt within the microcapsule. Initially, a maximum release rate was observed from microcapsules containing the lowest salt concentration. However, over time, the highest concentration released the greatest number of ions. Calcium, fluoride, and phosphate all contribute to the process of remineralization, and therefore, our efforts have demonstrated the potential for the incorporation into a variety of dental therapies capable of targeting the caries process.en_US
dc.language.isoen_USen_US
dc.publisherCreighton Universityen_US
dc.rightsCopyright is retained by the Author. A non-exclusive distribution right is granted to Creighton University and to ProQuest following the publishing model selected above.en_US
dc.subject.meshDentifrices ǂx pharmacology.en_US
dc.subject.meshDelayed-Action Preparations--chemistryen_US
dc.subject.meshResins, Syntheticen_US
dc.subject.meshTooth Remineralization--methodsen_US
dc.titleThe Release of Calcium, Fluoride, and Phosphate Ions from Ion Permeable Microcapsules in a Rosin Varnishen_US
dc.typeThesis
dc.rights.holderMichelle Falboen_US
dc.publisher.locationOmaha, Nebraskaen_US
dc.description.noteProQuest Traditional Publishing Optionen_US
dc.description.pagesvii, 62 pagesen_US
dc.contributor.cuauthorFalbo, Michelleen_US
dc.embargo.terms2014-05-15
dc.degree.levelMS (Master of Science)en_US
dc.degree.disciplineOral Biology (graduate program)en_US
dc.degree.nameM.S. in Oral Biologyen_US
dc.degree.grantorGraduate Schoolen_US
dc.degree.committeeNorton, Neil S.en_US


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