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dc.contributor.advisorGross, Stephen M.en_US
dc.contributor.authorCooper, Ryanen_US
dc.date.accessioned2013-05-13T18:19:50Z
dc.date.available2015-04-17T08:40:10Z
dc.date.issued2013-04-17en_US
dc.identifier.urihttp://hdl.handle.net/10504/42509
dc.description.abstractThe purpose of many dental products, including toothpaste, is to promote remineralization on the surface of the tooth. In this study, aqueous calcium nitrate salt and potassium phosphate salt solutions were encapsulated into microcapsules and added to toothpaste. This approach provided the toothpaste with a source of calcium ions and phosphate ions, which became bioavailable upon the brushing and rupturing of the microcapsules in the toothpaste. The analysis of the release of calcium and phosphate ions upon brushing demonstrated that large amounts of both ions were being released. Additionally, fluoride ions continued to be released from the active ingredient (sodium fluoride) in the toothpaste. By demonstrating the release of calcium ions, phosphate ions and fluoride ions to the oral environment, this approach promotes the precipitation of calcium fluoride and calcium phosphate salts that could lead to remineralization. The results from the study show strong support that toothpaste which contains aqueous calcium containing microcapsules and aqueous phosphate containing microcapsules could help reverse the demineralization process and advance the remineralization process on the surface of the tooth.en_US
dc.language.isoen_USen_US
dc.publisherCreighton Universityen_US
dc.rightsCopyright is retained by the Author. A non-exclusive distribution right is granted to Creighton University and to ProQuest following the publishing model selected above.en_US
dc.subject.meshToothpastes--pharmacologyen_US
dc.subject.meshTooth Remineralization--methodsen_US
dc.subject.meshCapsules--chemistryen_US
dc.subject.meshDelayed-Action Preparations--chemistryen_US
dc.subject.meshTooth Remineralization--methodsen_US
dc.subject.meshCapsules--chemistryen_US
dc.subject.meshPit and Fissure Sealantsen_US
dc.titleEncapsulation Of Calcium And Phosphate Ions In A Toothpaste Formulationen_US
dc.typeThesis
dc.rights.holderRyan Cooperen_US
dc.publisher.locationOmaha, Nebraskaen_US
dc.description.noteProQuest Traditional Publishing Optionen_US
dc.description.pagesvii, 48 pagesen_US
dc.contributor.cuauthorCooper, Ryanen_US
dc.embargo.terms2015-04-17
dc.degree.levelMS (Master of Science)en_US
dc.degree.disciplineOral Biology (graduate program)en_US
dc.degree.nameM.S. in Oral Biologyen_US
dc.degree.grantorGraduate Schoolen_US
dc.degree.committeeLatta, Mark A.en_US
dc.degree.committeeBarkmeier, Wayne W.en_US
dc.degree.committeeNorton, Neil S.en_US
dc.degree.committeeJensen, Gail M.en_US


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