This is a collection of patents assigned to Creighton University. The list includes expired as well as current patents.

Please use the browse indexes in the column on the right. Use the search box above to search the entire patent text (including the patent number).

Recent Submissions

  • Small Molecule Therapies for Pulmonary Hypertension 

    Tu, Yaping; Xie, Yan; Abel, Peter (United States Patent Office, 2019-09-24)
    The present disclosure relates to pirfenidone (5-methyl-lphenyl-2-(lH)-pyridone) and its derivatives and pharmaceutically acceptable salts thereof, use of these compounds as a medicament, and for the manufacture of a ...
  • Polymeric Nanoparticles in a Thermosensitive Gel for Coital-Independent Vaginal Prophylaxis of HIV 

    Destache, Chris; Date, Abhijit; Shibata, Annemarie (United States Patent Office, 2019-01-15)
    An antiretroviral composition that gels upon heating and can be administered prophylactically prior to exposure to a retrovirus following sexual intercourse, and methods of using the same.
  • Diffusion Cells and Related Methods 

    Munt, Daniel; Dash, Alekha (United States Patent Office, 2020-04-07)
    A method of performing a diffusion test includes clamping a membrane to a body such that a first surface of the membrane is in fluid communication with an interior chamber of the body and a second surface of the membrane ...
  • Liposomal Compositions with Light Illumination-Induced Drug Release 

    Meerovich, Igor; Dash, Alekha; Nichols, Michael; Smith, David (United States Patent Office, 2021-10-26)
    Provided herein is a small molecule delivery system with illumination-induced small molecule release based on the binary combination of charged liposomes containing small molecules and oppositely charged conjugates of a ...
  • Microtubule Polymerization Modulators for Treating LMNA-Related Dilated Cardiomyopathy 

    Wilcox, Jane Elizabeth; Prenosil, Joshua D. (United States Patent Office, 2018-06-21)
    Disclosed are methods and pharmaceutical compositions for treating cardiomyopathies. The disclosed methods and pharmaceutical compositions may be used for treating lamin A/C (LMNA)-related dilated cardiomyopathies (DCM) ...
  • High Resolution Melt-Curve Analysis to Identify the Sequence Type of E. Coli 

    Hanson, Nancy D.; Harrison, Lucas (United States Patent Office, 2021-02-02)
    Methods for differentiating E. coli sequence type 131 are described. In one implementation, a method that employs example techniques in accordance with the present disclosure for determining E. coli sequence type 131 ...
  • Indole-Based Therapeutics 

    North, Jeffrey; Jackson, Mary C. (United States Patent Office, 2019-08-20)
    Provided herein are indole-2-carboxamide compounds useful for the treatment of non-tuberculosis bacterial infections. Exemplary compounds provided herein are useful for the treatment of non-tuberculosis mycobacterial ...
  • Chemical Probes to Identify Anti-Mycobacterial MMPL3 Inhibitors 

    North, Jeffrey; Pandya, Amitkumar Navinchandra; Jackson, Mary; Li, Wei; Gonzalez-Juarrero, Mercedes (United States Patent Office, 2020-10-22)
    The present application provides detectable compounds useful for identifying compounds that bind (e.g., inhibit) MmpL3. Methods of identifying compounds that bind and/or inhibit MmpL3 are also provided.
  • Treatment and Prevention Methods for Mammalian Neurosensory Hair Cells Loss 

    Rocha-Sanchez, Sonia M. (United States Patent Office, 2018-03-27)
    The present disclosure relates to methods of treating acquired sensorineural hearing loss and/or ototoxicity in mammals by administering quinoxaline or a pharmaceutically acceptable derivative thereof. In implementations, ...
  • Seizure Therapy 

    Simeone, Kristina A.; Simeone, Timothy A. (United States Patent Office, 2017-07-11)
    A method and a composition are utilized to affect mitochondrial functions on a seizure-genic brain region. In one aspect, the disclosure comprises methods of treating seizures. Seizures are a transient symptom of abnormal ...
  • Stabilizing Instrumentation for the Performing of Endoscopic Surgical Procedures 

    Filipi, Charles J.; Cornet, Douglas A. (United States Patent Office, 1998-09-29)
    Apparatus and methods are disclosed for percutaneously providing a stabilized platform for performing endoscopic surgery. The disclosed instrumentation includes an endoscope, a fixation catheter, a loop suture, and a rigid ...
  • The High Bone Mass Gene of 11Q13.3 

    Carulli, John P.; Little, Randall D.; Recker, Robert R.; Johnson, Mark L. (European Patent Office, 2008-11-19)
    [Field of the Invention] The present invention relates generally to the field of genetics, genomics and molecular biology. More particularly, the invention relates to methods and materials used to isolate, detect and ...
  • Systems and Techniques for Minimally Invasive Gastrointestinal Procedures 

    Filipi, Charles J.; Addink, Jason L.; Klopfenstein, Scott D.; Moncur, Aaron B.; Hunt, Timothy B. (United States Patent Office, 2014-12-09)
    A surgical system for performing gastrointestinal procedures is disclosed. The system includes an elongated body defining an endoscope lumen. The body is adapted to be inserted into the esophagus with a proximal end extending ...
  • Tissue Resection Device and Method 

    Filipi, Charles J.; Hunt, Timothy B. (United States Patent Office, 2014-06-17)
    Among other things, embodiments of devices (and parts thereof) are disclosed that can be used in treating Barrett’s esophagus. Embodiments may have a suction cavity or window portion having elongated planar floor and ramped ...
  • Bite Blocks 

    Filipi, Charles J.; Hadley, Michael L. (United States Patent Office, 2014-09-02)
    Bite blocks providing an instrument lumen 62 for use during transoral medical procedures may be made from a material having a Shore D hardness less than 60 for improved patient comfort. An air way lumen 64 may be provide ...
  • Regulating Lipid Levels Via the ZMAX1 or HBM Gene 

    Carulli, John P.; Little, Randall D.; Recker, Robert R.; Johnson, Mark L. (European Patent Office, 2007-07-18)
    [Field of the Invention] The present invention relates generally to the field of genetics, genomics and molecular biology. The present disclosure relates to methods and materials used to isolate, detect and sequence ...
  • Polynucleotides for Use in Treating and Diagnosing Cancers 

    Xiao, Gary G. (United States Patent Office, 2014-09-23)
    The present invention provides methods for increasing sensitivity of cancer cells to an antiestrogen agent, such as a selective estrogen receptor modulator (SERM). The methods include administering to the subject a ...
  • Estrogen Receptors and Methods of Use 

    Wang, Zhao-Yi (United States Patent Office, 2013-12-31)
    The present invention provides isolated polypeptides having an amino acid sequence having at least 70% identity to SEQ ID NO:20, wherein the polypeptide has ER-a36 activity. The invention further provides methods for ...
  • Systems for Minimally Invasive Gastrointestinal Procedures 

    Filipi, Charles J. (European Patent Office, 2013-10-16)
    [Background] [0001] The present invention relates to surgical devices for excising mucosa in the stomach or esophagus and/or for securing portions of the stomach and esophagus together, e.g. to reduce the size of the ...
  • Systems and Techniques for Minimally Invasive Gastrointestinal Procedures 

    Filipi, Charles J.; Klopfenstein, Scott D.; Addink, Jason L. (United States Patent Office, 2014-02-04)
    A surgical system for performing gastroplasty is disclosed. The system includes an elongated body adapted to be inserted into the esophagus with a proximal end extending from a body orifice. A working member includes a ...

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