Now showing items 1-20 of 54

    • Treatment and Prevention Methods for Mammalian Neurosensory Hair Cells Loss 

      Rocha-Sanchez, Sonia M. (United States Patent Office, 2018-03-27)
      The present disclosure relates to methods of treating acquired sensorineural hearing loss and/or ototoxicity in mammals by administering quinoxaline or a pharmaceutically acceptable derivative thereof. In implementations, ...
    • Seizure Therapy 

      Simeone, Kristina A.; Simeone, Timothy A. (United States Patent Office, 2017-07-11)
      A method and a composition are utilized to affect mitochondrial functions on a seizure-genic brain region. In one aspect, the disclosure comprises methods of treating seizures. Seizures are a transient symptom of abnormal ...
    • Stabilizing Instrumentation for the Performing of Endoscopic Surgical Procedures 

      Filipi, Charles J.; Cornet, Douglas A. (United States Patent Office, 1998-09-29)
      Apparatus and methods are disclosed for percutaneously providing a stabilized platform for performing endoscopic surgery. The disclosed instrumentation includes an endoscope, a fixation catheter, a loop suture, and a rigid ...
    • Systems for Minimally Invasive Gastrointestinal Procedures 

      Filipi, Charles J. (European Patent Office, 2013-10-16)
      [Background] [0001] The present invention relates to surgical devices for excising mucosa in the stomach or esophagus and/or for securing portions of the stomach and esophagus together, e.g. to reduce the size of the ...
    • Self-Healing Dental Composites and Related Methods 

      Gross, Stephen M.; Latta, Mark A. (United States Patent Office, 2014-05-27)
      Dental restorative composites having self-healing capabilities to repair discontinuities in the composite are provided. Dental restorative composites according to the present invention include a microsphere that encapsulates ...
    • The High Bone Mass Gene of 11Q13.3 

      Carulli, John P.; Little, Randall D.; Recker, Robert R.; Johnson, Mark L. (European Patent Office, 2008-11-19)
      [Field of the Invention] The present invention relates generally to the field of genetics, genomics and molecular biology. More particularly, the invention relates to methods and materials used to isolate, detect and ...
    • System and Methods for Evaluating Efficacy of Appetite-Affecting Drugs 

      Reidelberger, Roger D. (United States Patent Office, 2015-03-10)
      System and methods to evaluate and administer drugs. The present invention instantaneously identifies the effects that drugs, including appetite-affecting agents, have on animals. Data is collected automatically and analyzed ...
    • Tissue Resection Device and Method 

      Filipi, Charles J.; Hunt, Timothy B. (United States Patent Office, 2014-06-17)
      Among other things, embodiments of devices (and parts thereof) are disclosed that can be used in treating Barrett’s esophagus. Embodiments may have a suction cavity or window portion having elongated planar floor and ramped ...
    • Bite Blocks 

      Filipi, Charles J.; Hadley, Michael L. (United States Patent Office, 2014-09-02)
      Bite blocks providing an instrument lumen 62 for use during transoral medical procedures may be made from a material having a Shore D hardness less than 60 for improved patient comfort. An air way lumen 64 may be provide ...
    • Bite Block with Airway Mount 

      Filipi, Charles J. (United States Patent Office, 2015-03-10)
      A bite block 20 for use during transoral medical procedures has a main lumen 42 and a side mount 110 for receiving a separately inserted airway 160. The airway 110 may be a commercially available nasopharangeal airway which ...
    • Polynucleotides for Use in Treating and Diagnosing Cancers 

      Xiao, Gary G. (United States Patent Office, 2014-09-23)
      The present invention provides methods for increasing sensitivity of cancer cells to an antiestrogen agent, such as a selective estrogen receptor modulator (SERM). The methods include administering to the subject a ...
    • Regulating Lipid Levels Via the ZMAX1 or HBM Gene 

      Carulli, John P.; Little, Randall D.; Recker, Robert R.; Johnson, Mark L. (European Patent Office, 2007-07-18)
      [Field of the Invention] The present invention relates generally to the field of genetics, genomics and molecular biology. The present disclosure relates to methods and materials used to isolate, detect and sequence ...
    • Estrogen Receptors and Methods of Use 

      Wang, Zhao-Yi (United States Patent Office, 2013-12-31)
      The present invention provides isolated polypeptides having an amino acid sequence having at least 70% identity to SEQ ID NO:20, wherein the polypeptide has ER-a36 activity. The invention further provides methods for ...
    • Systems and Techniques for Minimally Invasive Gastrointestinal Procedures 

      Filipi, Charles J.; Klopfenstein, Scott D.; Addink, Jason L. (United States Patent Office, 2014-02-04)
      A surgical system for performing gastroplasty is disclosed. The system includes an elongated body adapted to be inserted into the esophagus with a proximal end extending from a body orifice. A working member includes a ...
    • Systems and Techniques for Minimally Invasive Gastrointestinal Procedures 

      Filipi, Charles J.; Addink, Jason L.; Klopfenstein, Scott D.; Moncur, Aaron B.; Hunt, Timothy B. (United States Patent Office, 2014-12-09)
      A surgical system for performing gastrointestinal procedures is disclosed. The system includes an elongated body defining an endoscope lumen. The body is adapted to be inserted into the esophagus with a proximal end extending ...
    • Estrogen Receptors and Methods of Use 

      Wang, Zhao-Yi (United States Patent Office, 2013-08-20)
      The present invention provides isolated polypeptides having an amino acid sequence having at least 70% identity to SEQ ID NO:20, wherein the polypeptide has ER-a36 activity. The invention further provides methods for ...
    • Antibody that Binds to ER-a36 

      Wang, Zhao-Yi (United States Patent Office, 2011-09-06)
      The present invention provides isolated polypeptides having an amino acid sequence having at least 70% identity to SEQ ID NO:20, wherein the polypeptide has ER-a36 activity. The invention further provides methods for ...
    • Estrogen Receptors and Methods of Use 

      Wang, Zhao-Yi (United States Patent Office, 2013-10-08)
      The present invention provides isolated polypeptides having an amino acid sequence having at least 70% identity to SEQ ID NO:20, wherein the polypeptide has ER-a36 activity. The invention further provides methods for ...
    • Primers for Use in Detecting Beta-Lactamases 

      Hanson, Nancy D.; Sanders, Christine C.; Ehrhardt, Anton F. (United States Patent Office, 2009-01-13)
      Oliognucleotide primers are provided that are specific for nucleic acid characteristic of certain beta-lactamases. The primers can be employed in methods to identify nucleic acid characteristic of family-specific beta-lactamase ...
    • Mucoadhesive Nanoparticles for Cancer Treatment 

      Dash, Alekha K.; Trickler, William J. (United States Patent Office, 2012-08-14)
      The present invention relates to a pharmaceutical composition which includes nanoparticles. The nanoparticles include a glyceryl monooleate or monolinoleate (or other mono fatty acid ester); a chitosan; and a cancer ...