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    Polynucleotides for Use in Treating and Diagnosing Cancers

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    8841269.pdf (2.764Mb)
    Inventor(s)
    Xiao, Gary G.
    Creighton Inventor(s)
    Xiao, Gary G.
    Assignee
    Creighton University

    Application Number
    13/033056

    Date of Patent
    2014-09-23
    Patent Number
    US 8841269 B2

    Date of Application
    2011-02-23

    Metadata
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    Abstract
    The present invention provides methods for increasing sensitivity of cancer cells to an antiestrogen agent, such as a selective estrogen receptor modulator (SERM). The methods include administering to the subject a polynucleotide in an amount effective to increase the antiestrogen agent sensitivity of the cancer cells. The cancer cells may be estrogen receptor positive, such as ER-a66 positive or ER-a3 6 positive, prior to the administering. Also provided are methods for decreasing the amount of estrogen receptor present in a cancer cell, methods for determining whether antiestrogen agent sensitivity of cancer cells in a subj ect can be increased, methods for diagnosing whether a subject has, or is at risk for developing, cancer, and methods for identifying an agent that increases the amount of let-7 miRNA in a cell.
    URI
    http://hdl.handle.net/10504/68694
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