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dc.contributor.advisorSimeone, Kristina A.en_US
dc.contributor.authorIyer, Shruthi Hen_US
dc.date.accessioned2016-08-24T19:28:32Z
dc.date.available2018-08-16T08:40:22Z
dc.date.issued2016-08-16en_US
dc.identifier.urihttp://hdl.handle.net/10504/90263
dc.description.abstract[No Abstract, using the opening paragraph]|Epilepsy is a chronic, broad spectrum neurological disease which is characterized by recurrent and unprovoked seizures (Fisher et al. 2014). It is the fourth most common neurological disease affecting approximately 50 million people globally (Leonardi and Ustun 2002). In fact, it is estimated that about 1 in 26 people in the United States, will develop epilepsy during some point in their lifetime (Hesdorffer et al. 2011). The pathophysiology of epilepsy and seizures involves a chronic hyper excitability of the brain caused by hyperactive and hyper synchronous neuronal firing. This increase in neuronal excitability in epilepsy may be caused by a varied range of factors, channelopathies, and alterations in synaptic transmission, changes in levels of neurosteroids or neuropeptides or metabolic disorders. These abnormal changes may be the resultant of genetic abnormalities and developmental disorders, brain injury or trauma, stress or may be idiopathic in nature (Berg and Scheffer 2011; Shorvon 2011).en_US
dc.language.isoenen_US
dc.publisherCreighton Universityen_US
dc.rightsCopyright is retained by the Author. A non-exclusive distribution right is granted to Creighton University and to ProQuest following the publishing model selected above.en_US
dc.subject.meshDeath, Suddenen_US
dc.subject.meshEpilepsy--physiopathology.en_US
dc.titleSleep and cardiac dysfunction in Kv1.1 KO mice, a model of Sudden Unexpected Death in Epilepsy (SUDEP)en_US
dc.typeThesis
dc.rights.holderShruthi H Iyeren_US
dc.publisher.locationOmaha, Nebraskaen_US
dc.description.noteProQuest Traditional Publishing Optionen_US
dc.description.pagesviii, 86 pagesen_US
dc.contributor.cuauthorIyer, Shruthi Hen_US
dc.embargo.terms2018-08-16
dc.degree.levelMS (Master of Science)en_US
dc.degree.disciplinePharmacology (graduate program)en_US
dc.degree.nameM.S. in Pharmaceutical Sciencesen_US
dc.degree.grantorGraduate Schoolen_US
dc.degree.committeeAbel, Peter W.en_US
dc.degree.committeeDravid, Shashank M.en_US


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